Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PPAP2B contributors: KTN/npt - updated : 13/10/2008
HGNC name phosphatidic acid phosphatase type 2B
HGNC id 9229
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
 vessel   moderately
Digestivepancreas exocrine   moderately
Endocrineadrenal gland   moderately
Nervousnerve   highly
Reproductivefemale systemplacenta  predominantly
 female systemuterus  moderately
Respiratoryrespiratory tractlarynx  moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  moderately
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text predominantly in placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to dog PPAP2B (96.8 pc)
homolog to cow PPAP2B (95.2 pc)
homolog to rattus Ppap2b (94.9 pc)
homolog to murine Ppap2b (94.9 pc)
homolog to chicken PPAP2B (83.6 pc)
Homologene
FAMILY
  • PAP2 superfamily
  • PA-phosphatase related phosphoesterase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • trans-Golgi network membrane
  • multi-pass membrane protein
  • type 2 plasma membrane-bound enzyme
  • basic FUNCTION
  • catalyzing the conversion of phosphatidic acid to diacylglycerol
  • hydrolyzing lysophosphatidic acid, ceramide-1-phosphate and sphingosine-1-phosphate
  • may be involved in cell adhesion and in cell-cell interactions
  • involved in regulation of Wnt receptor signaling pathway
  • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS development
    text
  • blood vessel development
  • gastrulation with mouth forming second
  • germ cell migration
  • PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
  • complex confering only structural or functional stability
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by sphingosine, zinc ions and propanolol
    epidermal growth factor (EGF), vascular endothelial growrh factor (VEGF), basic fibroblast growth factor (bFGF) and phorbol myristate acetate (PMA)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    inactivated in renal clear cell carcinomas with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS