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FLASH GENE

Symbol

POU4F2

contributors: mct - updated : 05-01-2008

HGNC name	POU domain, class 4, transcription factor 2
HGNC id	9219

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	4q31.2      Physical location : 147.560.044 - 147.563.622
Synonym name	Brn3b POU domain transcription factor
	brain-specific homeobox/POU domain protein 3B
	POU domain protein
Synonym symbol(s)	BRN3B, BRN3.2, Brn-3b

DNA

TYPE	functioning gene
STRUCTURE	3.58 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004575 2 - 3141 NP_004566 - 409 - 2007 17490655

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis       Visual eye retina

cells

System Cell Pubmed Species Stage Rna symbol Visual ganglion cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	DNA binding protein, with POU specific and homeo domains
	a glycine /serine-rich domain
	a histidine rich domain

HOMOLOGY

interspecies

homolog to C.elegans c30a5.7b

Homologene

FAMILY

class IV Pou homeodomain family of transcription factors

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	playing a role in determining or maintaining the identities of a small subset of visual system neurons
	playing a role in regulating mammary cell growth
	key regulator of retinal ganglion cells
	ISL1 and POU4F2 concurrently bind to and synergistically regulate the expression of a common set of retinal ganglion cells-specific genes

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

text	neurogenesis
	eye morphogenesis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein	regulates plakoglobin
	interacts with the estrogen receptor (ER) and in association with the ER, regulates transcription from estrogen responsive genes

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast cancer cells

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS