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FLASH GENE
Symbol POU4F2 contributors: mct - updated : 05-01-2008
HGNC name POU domain, class 4, transcription factor 2
HGNC id 9219
Location 4q31.2      Physical location : 147.560.044 - 147.563.622
Synonym name
  • Brn3b POU domain transcription factor
  • brain-specific homeobox/POU domain protein 3B
  • POU domain protein
  • Synonym symbol(s) BRN3B, BRN3.2, Brn-3b
    DNA
    TYPE functioning gene
    STRUCTURE 3.58 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3141 - 409 - 2007 17490655
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    Visualeyeretina   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualganglion cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • DNA binding protein, with POU specific and homeo domains
  • a glycine /serine-rich domain
  • a histidine rich domain
  • HOMOLOGY
    interspecies homolog to C.elegans c30a5.7b
    Homologene
    FAMILY
  • class IV Pou homeodomain family of transcription factors
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in determining or maintaining the identities of a small subset of visual system neurons
  • playing a role in regulating mammary cell growth
  • key regulator of retinal ganglion cells
  • ISL1 and POU4F2 concurrently bind to and synergistically regulate the expression of a common set of retinal ganglion cells-specific genes
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text
  • neurogenesis
  • eye morphogenesis
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • regulates plakoglobin
  • interacts with the estrogen receptor (ER) and in association with the ER, regulates transcription from estrogen responsive genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS