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FLASH GENE
Symbol POU4F2 contributors: mct - updated : 05-01-2008
HGNC name POU domain, class 4, transcription factor 2
HGNC id 9219
DNA
TYPE functioning gene
STRUCTURE 3.58 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 3141 - 409 - 2007 17490655
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
Visualeyeretina   
cells
SystemCellPubmedSpeciesStageRna symbol
Visualganglion cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DNA binding protein, with POU specific and homeo domains
  • a glycine /serine-rich domain
  • a histidine rich domain
  • HOMOLOGY
    interspecies homolog to C.elegans c30a5.7b
    Homologene
    FAMILY
  • class IV Pou homeodomain family of transcription factors
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in determining or maintaining the identities of a small subset of visual system neurons
  • playing a role in regulating mammary cell growth
  • key regulator of retinal ganglion cells
  • ISL1 and POU4F2 concurrently bind to and synergistically regulate the expression of a common set of retinal ganglion cells-specific genes
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text
  • neurogenesis
  • eye morphogenesis
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • regulates plakoglobin
  • interacts with the estrogen receptor (ER) and in association with the ER, regulates transcription from estrogen responsive genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS