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FLASH GENE
Symbol POU3F1 contributors: mct/npt - updated : 16-07-2008
HGNC name POU class 3 homeobox 1
HGNC id 9214
Location 1p34.1      Physical location : 38.509.522 - 38.512.450
Synonym name
  • POU domain, class 3, transcription factor 1
  • octamer-binding transcription factor 6
  • POU domain transcription factor SCIP
  • Synonym symbol(s) OTF6, OCT6, SCIP
    DNA
    TYPE functioning gene
    STRUCTURE 2.00 kb     1 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ23231 1p34.2 hypothetical protein FLJ23231 FLJ11730 1p35.3-p33 hypothetical protein FLJ11730 SNIP1 1p34.2 Smad nuclear interacting protein DNALI1 1p35.1 dynein, axonemal, light intermediate polypeptide 1 HUMAUANTIG 1p34.2 nucleolar GTPase FLJ40906 1p34.2 hypothetical protein FLJ40906 FLJ20508 1p34.2 hypothetical protein FLJ20508 CDCA8 1p34.2 cell division cycle associated 8 FLJ33655 1p34.2 hypothetical protein FLJ33655 LOC391026 1 similar to actinin, alpha 4 LOC391027 1 similar to chromosome 14 open reading frame 138 FLJ31434 1p34.2 hypothetical protein FLJ31434 FLJ45459 1p34.2 FLJ45459 protein SF3A3 1p34.1 splicing factor 3a, subunit 3, 60kDa FHL3 1p34.2-p32.3 four and a half LIM domains 3 CGI-94 1p34.2 comparative gene identification transcript 94 POU3F1 1p34.1 POU domain, class 3, transcription factor 1 LOC343259 1p34.2 similar to 78 kDa glucose-regulated protein precursor (GRP 78) (Immunoglobulin heavy chain binding protein) (BiP) (Endoplasmic reticulum lumenal Ca(2+) binding protein grp78) RRAGC 1p34 Ras-related GTP binding C MYCBP 1p33-p32.2 c-myc binding protein GJA10 1p35-p34 gap junction protein, alpha 10, 59kDa RHBDL2 1p35.1 rhomboid, veinlet-like 2 (Drosophila) FLJ12666 1p34.2 hypothetical protein FLJ12666 NDUFS5 1p34.2-p33 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) MACF1 1p32-p31 microtubule-actin crosslinking factor 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2928 - 451 - Ryu (2007)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear    
    Nervousbrain    
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmature hematopoietic
    cell lineage
    cell lines leukemia cells
    fluid/secretion
    at STAGE
    physiological period embryo
    Text embryonal stem cells, developing brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • POU specific and POU homeo (helix-turn-helix) domains
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Pou3f.1
    homolog to C.elegans k02b12.1
    intraspecies homolog to POU3F4
    Homologene
    FAMILY
  • POU transcription factor family
  • class-3 subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in early embryogenesis and neurogenesis
  • playing a critical role in the cellular uptake and efflux of endogenous cationic substrates and hydrophilic exogenous xenobiotics
  • important regulator of peripheral nerve myelination by Schwann cells
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • POU specific and POU homeo (helix-turn-helix) domains, forming homo or heterodimers
  • INTERACTION
    DNA binding to the octamer motif ATTTGCAT
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    results in peripheral nerve hypomyelination and axonal loss
    Susceptibility
    Variant & Polymorphism
    Candidate gene may be a marker for dedifferentiation of adult Schwann cells and active nerve regeneration
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    OCT 6-/- mice (Jaegle, 96)