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FLASH GENE
Symbol POU3F1 contributors: mct/npt - updated : 16-07-2008
HGNC name POU class 3 homeobox 1
HGNC id 9214
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     1 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 2928 - 451 - Ryu (2007)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumear    
Nervousbrain    
Skin/Tegumentskin    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmature hematopoietic
cell lineage
cell lines leukemia cells
fluid/secretion
at STAGE
physiological period embryo
Text embryonal stem cells, developing brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • POU specific and POU homeo (helix-turn-helix) domains
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Pou3f.1
    homolog to C.elegans k02b12.1
    intraspecies homolog to POU3F4
    Homologene
    FAMILY
  • POU transcription factor family
  • class-3 subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in early embryogenesis and neurogenesis
  • playing a critical role in the cellular uptake and efflux of endogenous cationic substrates and hydrophilic exogenous xenobiotics
  • important regulator of peripheral nerve myelination by Schwann cells
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • POU specific and POU homeo (helix-turn-helix) domains, forming homo or heterodimers
  • INTERACTION
    DNA binding to the octamer motif ATTTGCAT
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    results in peripheral nerve hypomyelination and axonal loss
    Susceptibility
    Variant & Polymorphism
    Candidate gene may be a marker for dedifferentiation of adult Schwann cells and active nerve regeneration
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    OCT 6-/- mice (Jaegle, 96)