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FLASH GENE

Symbol

POLA2

contributors: - updated : 05-07-2005

HGNC name	polymerase (DNA directed), alpha 2 (70kD subunit)
HGNC id	30073

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q13.1      Physical location : 65.029.431 - 65.065.087

DNA

TYPE	functioning gene
STRUCTURE	35.00 kb     18 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly   mouth tongue     moderately Lymphoid/Immune lymph node       moderately Reproductive female system uterus cervix   predominantly Respiratory lung       lowly   respiratory tract larynx     lowly Urinary bladder       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

PhosphoP

HOMOLOGY

interspecies	ortholog to rattus Pola2
	ortholog to murine Pola2

Homologene

FAMILY

DNA polymerase alpha subunit B family

CATEGORY

enzyme , DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome,euchromosome

basic FUNCTION

may play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery

CELLULAR PROCESS

nucleotide, replication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

phosphorylated in a cell cycle-dependent manner, in G2/M phase

INTERACTION

DNA

binding

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS