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FLASH GENE
Symbol POLA2 contributors: - updated : 05-07-2005
HGNC name polymerase (DNA directed), alpha 2 (70kD subunit)
HGNC id 30073
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 mouthtongue  moderately
Lymphoid/Immunelymph node   moderately
Reproductivefemale systemuteruscervix predominantly
Respiratorylung   lowly
 respiratory tractlarynx  lowly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP
HOMOLOGY
interspecies ortholog to rattus Pola2
ortholog to murine Pola2
Homologene
FAMILY
  • DNA polymerase alpha subunit B family
  • CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,euchromosome
    basic FUNCTION
  • may play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • phosphorylated in a cell cycle-dependent manner, in G2/M phase
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS