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FLASH GENE
Symbol PODN contributors: - updated : 10-02-2006
HGNC name podocan
HGNC id 23174
Location 1p32.3      Physical location : 53.527.884 - 53.551.173
Synonym symbol(s) PCAN, MGC24995, SLRR5A
DNA
TYPE functioning gene
STRUCTURE 23.00 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
RNF11 1p32-p31 ring finger protein 11 LOC388631 1 similar to ribosomal protein S2; 40S ribosomal protein S2 C1orf34 1p33 chromosome 1 open reading frame 34 EPS15 1p32.2-p31 epidermal growth factor receptor pathway substrate 15 OSBPL9 1p34.2-p32.2 oxysterol binding protein-like 9 NRD1 1p32.2 nardilysin (N-arginine dibasic convertase) RAB3B 1p32-p31 RAB3B, member RAS oncogene family TLP19 1p32.3 endoplasmic reticulum thioredoxin superfamily member, 18 kDa LOC112970 1p32.3 hypothetical protein BC012173 LOC391040 1 similar to RIKEN cDNA 5730434I03 gene MADHIP 1p32.3 MAD, mothers against decapentaplegic homolog (Drosophila) interacting protein, receptor activation anchor KIAA1836 1p32.3 KIAA1836 protein ORC1L 1p32 origin recognition complex, subunit 1-like (yeast) FLJ14936 1p33-p32.1 hypothetical protein FLJ14936 KIAA0191 1p31-32 hypothetical protein FLJ14936 GPX6 6p21.33 glutathione peroxidase 6 (olfactory) MGC52498 1p32.3 hypothetical protein MGC52498 FLJ12439 1p32.3 hypothetical protein FLJ12439 FLJ13456 1p32.3 hypothetical protein FLJ13456 FLJ10948 1p32.3 hypothetical protein FLJ10948 SCP2 1p32 sterol carrier protein 2 PODN 1p32.3 podocan SLC1A7 1p33 solute carrier family 1 (glutamate transporter), member 7 CPT2 1p32 carnitine palmitoyltransferase II FLJ20580 1p32.3 hypothetical protein FLJ20580 MAGOH 1p34-p33 mago-nashi homolog, proliferation-associated (Drosophila) LRP8 1p34 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor FLJ40434 1p32.3 hypothetical protein FLJ40434 DMRTB1 1p33 DMRT-like family B with proline-rich C-terminal, 1 FLJ36155 1p32.3 likely ortholog of mouse Gli-similar 1 Kruppel-like zinc finger (Glis1) FLJ10407 1p32.3 hypothetical protein FLJ10407 DJ167A19.1 1p33-p32.1 hypothetical protein DJ167A19.1 DIO1 1p32-p33 deiodinase, iodothyronine, type I LOC51668 1p32.1-p33 HSPCO34 protein MGC8974 1p33-p32.1 hypothetical protein MGC8974 LOC388632 1 similar to heterogeneous nuclear ribonucleoprotein A3 LOC388633 1 similar to Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330) C1orf8 1p36-p31 chromosome 1 open reading frame 8 FLJ32112 1p32.3 hypothetical protein FLJ32112 LOC343190 LOC200008 1p32.3 hypothetical protein LOC200008 MRPL37 1p32.1 mitochondrial ribosomal protein L37 SSBP3 1p31.3 single stranded DNA binding protein 3 LOC391041 1 hypothetical gene supported by BC004945 THEA 1p31.3 thioesterase, adipose associated MGC27169  hyporthetical protein MGC27169 TTC4 1p31.3 tetratricopeptide repeat domain 4 DKFZp727A071 1p32.2 similar to tRNA synthetase class II
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinesmall intestine   
Reproductivemale systemprostate   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmoothvessel  
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell
Urinarypodocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal cysteine-rich cluster pattern
  • a leucine-rich-repeat (LRR) domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus LOC313483
    ortholog to murine Podn
    Homologene
    FAMILY small leucine-rich repeat (SLR) protein family
    CATEGORY regulatory , secretory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    text cytoplasmic in glomeruli, secreted from podocytes
    basic FUNCTION
  • proteoglycan that may regulate and maintain extracellular matrix collagen fibrils
  • may have a potential role in growth regulation in cardiovascular tissues
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein bind type 1 collagen
    cell & other
    REGULATION
    Other up-regulated in HIV transgenic cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the sclerotic glomerular lesion of HIVAN
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS