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FLASH GENE
Symbol PODN contributors: - updated : 10-02-2006
HGNC name podocan
HGNC id 23174
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinesmall intestine   
Reproductivemale systemprostate   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmoothvessel  
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell
Urinarypodocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal cysteine-rich cluster pattern
  • a leucine-rich-repeat (LRR) domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus LOC313483
    ortholog to murine Podn
    Homologene
    FAMILY small leucine-rich repeat (SLR) protein family
    CATEGORY regulatory , secretory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    text cytoplasmic in glomeruli, secreted from podocytes
    basic FUNCTION
  • proteoglycan that may regulate and maintain extracellular matrix collagen fibrils
  • may have a potential role in growth regulation in cardiovascular tissues
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein bind type 1 collagen
    cell & other
    REGULATION
    Other up-regulated in HIV transgenic cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the sclerotic glomerular lesion of HIVAN
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS