Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

POC1A

contributors: mct - updated : 05-09-2012

HGNC name	POC1 centriolar protein homolog A
HGNC id	24488

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	MOPD4 microcephalic osteodysplastic primordial dwarfism type 4
Location	3p21.2      Physical location : 52.109.249 - 52.188.706
Synonym name	WD repeat-containing protein 51A
Synonym symbol(s)	PIX2, WDR51A

DNA

TYPE	functioning gene
STRUCTURE	79.46 kb     11 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001161580 10 - 2069 NP_001155052 - 359 - 2008 18068700 NM_015426 11 - 2213 NP_056241 - 407 - 2008 18068700 NM_001161581 11 - 2284 NP_001155053 - 369 - 2008 18068700

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal WD40 domain, which forms a seven-bladed beta-propeller
	C-terminal coiled-coil

HOMOLOGY

Homologene

FAMILY

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
text	localize to centrosomes and associate with microtubules

basic FUNCTION	POC1A and POC1B are WD40 microtubule-associated proteins that colocalize with centrosomes in human cells
	POC1A and POC1B are microtubule-associated adaptor proteins that likely contribute to a range of developmental and cell division processes
	essential role in centrosome function

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MOPD4

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS