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FLASH GENE
Symbol POC1A contributors: mct - updated : 05-09-2012
HGNC name POC1 centriolar protein homolog A
HGNC id 24488
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal WD40 domain, which forms a seven-bladed beta-propeller
  • C-terminal coiled-coil
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • localize to centrosomes and associate with microtubules
  • basic FUNCTION
  • POC1A and POC1B are WD40 microtubule-associated proteins that colocalize with centrosomes in human cells
  • POC1A and POC1B are microtubule-associated adaptor proteins that likely contribute to a range of developmental and cell division processes
  • essential role in centrosome function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MOPD4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS