protein
| PLK1 likely maintains the integrity of the spindle poles by phosphorylating KIZ |
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interacting directly with ERCC6L (recruits PLK1 to chromosome arms and disruption of this interaction abolishes PLK1 localization on chromosome arms) |
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PLK1 controls AURKA localization and function by regulating cellular levels of BORA |
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BORA/AURKA-dependent phosphorylation is a prerequisite for PLK1 to promote mitotic entry after a checkpoint-dependent arrest |
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KIF2A is regulated positively by PLK1 and negatively by Aurora A |
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SEPT9 is a putative binding partner of PLK1, which has been shown to act as a regulator of cytokinesis |
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binds and directly phosphorylates the RACGAP subunit of centralspindlin (also known as RACGAP1) at the midzone |
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PLK1 associates with TUBG1 in mitosis and PLK1 activity contributes to phosphorylation of TUBG1 |
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interacting with BIRC5 during mitosis and PLK1 phosphorylates survivin at serine 20, which is essential for accurate chromosome alignment and cell proliferation but is dispensable for its anti-apoptotic activity in cancer cells |
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DCTN1 interacts with PLK1 through its C-terminal polo-box domain, which was proposed as the motif for association with its substrates |
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MAP9 and PLK1 co-localize and interact at spindle poles during mitosis and this interaction requires specifically the PBD of PLK1 |
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CLIP1 is a potential PLK1 target (interacts with PLK1 through its N-terminus) |
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PLK1 binds the GORASP1 C-terminal domain under mitotic conditions |
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PLK1 activity negatively regulates CEP55 to ensure orderly abscission factor recruitment and ensures that this occurs only once cell contraction has completed |
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interacts with the MLF1IP-CENPQ complex and regulates its dissociation from mitotic kinetochores |
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RNF8 is downregulated in many cancer cells and inversely correlated with PLK1 |
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PLK1 interacts with the DExH/D RNA helicase, DDX39B |
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via the formation of the NEDD1-PLK1 complex and subsequent HAUS8 phosphorylation, PLK11 regulates spindle MT-based MT nucleation to accomplish normal bipolar spindle formation and mitotic progression |
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PLK1 controls the NEK2-PPP1CC antagonism in centrosome disjunction |
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one of ATXN10 binding partners |
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RIOK2 interacts with the N-terminal domain of PLK1 |
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ORC2 is a PLK1 substrate and PLK1 phosphorylates ORC2 at Ser188 |
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CEP55 associates with and is phosphorylated by PLK1 during mitosis (tight regulation of CEP55 protein levels by TP53 is mediated by PLK1 phosphorylation) |
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PLK1-mediated phosphorylation of pericentriolar matrix initiates centrosome maturation by organizing the spindle pole-specific PCM lattice |
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OPTN is associated with a myosin phosphatase complex (MP), which antagonizes the mitotic function of PLK1 |
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TEX14 is recruited to kinetochores (KTs) by PLK1 in a CDK1-dependent manner during early mitosis |
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TCOF1 and PLK1 are novel regulators of spindle fidelity, mitotic progression, and proliferation in the maintenance and localization of neural progenitor cells |
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PLK1 directly phosphorylates KIF2B at threonine 125 (T125) and serine 204 (S204), and these two sites differentially regulate KIF2B function |
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negatively regulates PRC1 to prevent premature midzone formation before cytokinesis (PMIDF: |
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FRY binds to PLK1 and AURKA and promotes AURKA-mediated PLK1 activation |
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PLK1, phosphorylates central element proteins SYCP1 and TEX12, and PLK-mediated phosphorylation of central element proteins is required for meiotic prophase exit |
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SUGT1, a cochaperone for HSP90AA1, 1s a novel PLK1 substrate during mitosis |
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EIF4EBP1, beyond its role in translation regulation, can function as a regulator of mitosis via interacting with PLK1, and possibly plays a role in genomic stability maintaining |
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during mitosis the kinetochore (KT)-microtubule (MT)-associated protein CLASP2 is progressively and distinctively phosphorylated by CDK1 and PLK1 kinases, concomitant with the establishment of KT-MT attachments |
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PLK1 and BUB1B cooperate to stabilize kinetochore-microtubule interactions by regulating PP2A-B56alpha-mediated dephosphorylation of AURKB substrates at the kinetochore-microtubule interface |
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PLK1 phosphorylates MISP, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning |
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CIP2A is required for mitotic progression by regulating the polo-like kinase PLK1 |
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recruitment of PLK1 to centrosomes by FOPNL may act as a signal to license efficient progression of S-phase |
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BRCA1 downregulates the kinase activity of PLK1 by modulating the dynamic interactions of AURKA, BORA, and PLK1 |
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STMN1 regulates mitotic entry, partially via MTs, to control localization and activation of both AURKA and PLK1 |
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BRCA2, a key RAD51 binding partner, coordinates the activity of the central cell-cycle drivers CDKs and PLK1 to promote RAD51-mediated genome stability control |
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PLK1 regulates KIF2C potentially by regulating its degradation and hence controlling its turnover in mitosis |
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NCAPG2 directly interacts with the polo-box domain (PBD) of PLK1 via its highly conserved C-terminal region |
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CENPQ targets PLK1 to kinetochores and is also required for the recruitment of CENPE to kinetochores |
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BRCA1 and BRIP1 cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of PLK1 |
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mitotic phosphorylation of TP53BP1 by PLK1 and CDK1 that impairs the ability of TP53BP1 to bind the ubiquitinated H2A and to properly localize to the sites of DNA damage |
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is the responsible kinase for phosphorylation of IRS2 on two serine residues |
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NAXE functions as a negative regulator to block phosphorylation of NIN mediated by AURKA and PLK1 |
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RSF1 directly binds PLK1 |
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USP16 deubiquitinates PLK1, resulting in an enhanced interaction with kinetochore-localized proteins such as BUB1B, and thereby retains PLK1 on the kinetochores to promote proper chromosome alignment in early mitosis |
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USP16 promotes the localization and maintenance of PLK1 on the kinetochores for proper chromosome alignment |
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TOPBP1 physically binds PLK1 and promotes PLK1 kinase-mediated phosphorylation of RAD51 at serine 14, a modification required for RAD51 recruitment to chromatin |
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interaction between KMT2E and PLK1 in the cytosol that is crucial for sustaining spindle bipolarity during mitosis |
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PPP1R12A localization to kinetochores depends on CCNA1/CDK1 activity and PPP1R12A destabilizes kinetochore microtubule (k-MT) attachments by negatively regulating PLK1 at kinetochores |
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PLK1 kinase activity was required for ubiquitin& |
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8209;dependent degradation of RNF2 |
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TPX2 promotes the proliferation and migration of human Ovarian cancer cells by regulating PLK1 expression |
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ripoptosome-mediated regulation of PLK1 contributes to faithful chromosome segregation during mitosis |
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PLK1 is recruited into mitotic ripoptosomes, where PLK1's activity is controlled via RIPK1-dependent recruitment and CASP8-mediated cleavage |
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PLK1 plays a critical role in maintaining intralysosomal pH by regulating ATP6V1A phosphorylation |