| 1 | ATP6V1A, PLK1
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| Plk1 promotes renal tubulointerstitial fibrosis by targeting autophagy/lysosome axis.
|
| Du Y, Shang Y, Qian Y, Guo Y, Chen S, Lin X, Cao W, Tang X, Zhou A, Huang S, Zhang A, Jia Z, Zhang Y.
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| Cell Death Dis. Aug 29;14(8):571. doi: 10.1038/s41419-023-06093-4. 2023
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| 2 | CEP97, DYRK1A, PLK1
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| CEP97 phosphorylation by Dyrk1a is critical for centriole separation during multiciliogenesis.
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| Lee M, Nagashima K, Yoon J, Sun J, Wang Z, Carpenter C, Lee HK, Hwang YS, Westlake CJ, Daar IO.
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| J Cell Biol. Jan 3;221(1):e202102110. doi: 10.1083/jcb.202102110. Epub 2021 Nov 17. 2022
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| 3 | PELO, PLK1
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| PELO facilitates PLK1-induced the ubiquitination and degradation of Smad4 and promotes the progression of prostate cancer
|
| Gao P, Hao JL, Xie QW, Han GQ, Xu BB, Hu H, Sa NE, Du XW, Tang HL, Yan J, Dong XM.
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| Oncogene. May;41(21):2945-2957. doi: 10.1038/s41388-022-02316-8. Epub 2022 Apr 18. 2022
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| 4 | CASP8, PLK1, RIPK1
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| RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation.
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| Liccardi G, Ramos Garcia L, Tenev T, Annibaldi A, Legrand AJ, Robertson D, Feltham R, Anderton H, Darding M, Peltzer N, Dannappel M, Schünke H, Fava LL, Haschka MD, Glatter T, Nesvizhskii A, Schmidt A, Harris PA, Bertin J, Gough PJ, Villunger A, Silke J, Pasparakis M, Bianchi K, Meier P.
|
| Mol Cell 73(3):413-428.e7. doi: 10.1016/j.molcel.2018.11.010. Epub 2018 Dec 28.
2019
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| 5 | PLK1, RNF2
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| Plk1 interacts with RNF2 and promotes its ubiquitin‑dependent degradation.
|
| An R, Cheng L, Chen L, Du J.
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| Oncol Rep 39(5):2358-2364. doi: 10.3892/or.2018.6326. Epub 2018 Mar 20.
2018
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| 6 | PLK1, TPX2
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| TPX2 promotes cell proliferation and migration via PLK1 in OC.
|
| Ma S, Rong X, Gao F, Yang Y, Wei L.
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| Cancer Biomark 22(3):443-451. doi: 10.3233/CBM-171056.
2018
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| 7 | DZIP1, PLK1
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| DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle.
|
| Zhang B, Wang G, Xu X, Yang S, Zhuang T, Wang G, Ren H, Cheng SY, Jiang Q, Zhang C.
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| J Biol Chem 292(4):1351-1360. doi: 10.1074/jbc.M116.765438. Epub 2016 Dec 15.
2017
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| 8 | CCNA1, CDK1, PLK1, PPP1R12A
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| Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability.
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| Dumitru AMG, Rusin SF, Clark AEM, Kettenbach AN, Compton DA.
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| Elife 6. pii: e29303. doi: 10.7554/eLife.29303.
2017
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| 9 | PLK1, RAD51, TOPBP1
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| TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity.
|
| Moudry P, Watanabe K, Wolanin KM, Bartkova J, Wassing IE, Watanabe S, Strauss R, Troelsgaard Pedersen R, Oestergaard VH, Lisby M, Andújar-Sánchez M, Maya-Mendoza A, Esashi F, Lukas J, Bartek J.
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| J Cell Biol 212(3):281-8. doi: 10.1083/jcb.201507042.
2016
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| 10 | KMT2E, PLK1
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| MLL5 maintains spindle bipolarity by preventing aberrant cytosolic aggregation of PLK1.
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| Zhao W, Liu J, Zhang X, Deng LW.
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| J Cell Biol 212(7):829-43. doi: 10.1083/jcb.201501021. Epub 2016 Mar 21.
2016
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| 11 | BUB1B, PLK1, USP16
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| Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis.
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| Zhuo X, Guo X, Zhang X, Jing G, Wang Y, Chen Q, Jiang Q, Liu J, Zhang C.
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| J Cell Biol 210(5):727-35. doi: 10.1083/jcb.201502044.
2015
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| 12 | PLK1
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| Plk1 relieves centriole block to reduplication by promoting daughter centriole maturation.
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| Shukla A, Kong D, Sharma M, Magidson V, Loncarek J.
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| Nat Commun 6:8077. doi: 10.1038/ncomms9077.
2015
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| 13 | PLK1, SPAG9
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| JIP4 is a PLK1 binding protein that regulates p38MAPK activity in G2 phase.
|
| Pinder A, Loo D, Harrington B, Oakes V, Hill MM, Gabrielli B.
|
| Cell Signal 27(11):2296-303. doi: 10.1016/j.cellsig.2015.08.009. Epub 2015 Aug 17.
2015
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| 14 | IRS2, PLK1
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| Plk1 phosphorylation of IRS2 prevents premature mitotic exit via AKT inactivation.
|
| Chen L, Li Z, Ahmad N, Liu X.
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| Biochemistry 54(15):2473-80. doi: 10.1021/acs.biochem.5b00016. Epub 2015 Apr 6.
2015
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| 15 | CDK1, PLK1, TP53
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| Polo-like kinase 1 inhibits DNA damage response during mitosis.
|
| Benada J, Burdová K, Lidak T, von Morgen P, Macurek L.
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| Cell Cycle 14(2):219-31. doi: 10.4161/15384101.2014.977067.
2015
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| 16 | AURKA, NAXE, NIN, PLK1
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| AIBp regulates mitotic entry and mitotic spindle assembly by controlling activation of both Aurora-A and Plk1.
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| Chou CH, Loh JK, Yang MC, Lin CC, Hong MC, Cho CL, Chou AK, Wang CH, Lieu AS, Howng SL, Hsu CM, Hong YR.
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| Cell Cycle 14(17):2764-76. doi: 10.1080/15384101.2015.1066536.
2015
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| 17 | PLK1, RSF1
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| The chromatin remodeller RSF1 is essential for PLK1 deposition and function at mitotic kinetochores.
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| Lee HS, Park YY, Cho MY, Chae S, Yoo YS, Kwon MH, Lee CW, Cho H.
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| Nat Commun 6:7904. doi: 10.1038/ncomms8904.
2015
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| 18 | CDKN1A, NFYA, PLK1
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| Association of p21 with NF-YA suppresses the expression of Polo-like kinase 1 and prevents mitotic death in response to DNA damage.
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| Lin YC, Chen YN, Lin KF, Wang FF, Chou TY, Chen MY.
|
| Cell Death Dis 5:e987. doi: 10.1038/cddis.2013.527.
2014
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| 19 | BRCA1, BRIP1, PLK1
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| BRCA1 and FancJ cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1.
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| Zou J, Zhang D, Qin G, Chen X, Wang H, Zhang D.
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| Cell Cycle 13(23):3685-97. doi: 10.4161/15384101.2014.964973.
2014
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| 20 | PLK1
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| Centriole maturation requires regulated Plk1 activity during two consecutive cell cycles.
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| Kong D, Farmer V, Shukla A, James J, Gruskin R, Kiriyama S, Loncarek J.
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| J Cell Biol 206(7):855-65. doi: 10.1083/jcb.201407087. Epub 2014 Sep 22.
2014
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| 21 | KIF2C, PLK1
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| Polo-like kinase 1 regulates the stability of the mitotic centromere-associated kinesin in mitosis.
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| Sanhaji M, Ritter A, Belsham HR, Friel CT, Roth S, Louwen F, Yuan J.
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| Oncotarget 5(10):3130-44.
2014
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| 22 | CLIP1, PLK1
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| CLIP-170 recruits PLK1 to kinetochores during early mitosis for chromosome alignment.
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| Amin MA, Itoh G, Iemura K, Ikeda M, Tanaka K.
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| J Cell Sci 127(Pt 13):2818-24. doi: 10.1242/jcs.150755. Epub 2014 Apr 28.
2014
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| 23 | CLIP1, PLK1
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| Plk1 phosphorylates CLIP-170 and regulates its binding to microtubules for chromosome alignment.
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| Kakeno M, Matsuzawa K, Matsui T, Akita H, Sugiyama I, Ishidate F, Nakano A, Takashima S, Goto H, Inagaki M, Kaibuchi K, Watanabe T.
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| Cell Struct Funct 39(1):45-59. Epub 2014 Jan 22.
2014
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| 24 | PLK1, STK11
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| Liver kinase B1 regulates the centrosome via PLK1.
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| Werle K, Chen J, Xu HG, Zhao RX, He Q, Lu C, Cui R, Liang J, Li YL, Xu ZX.
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| Cell Death Dis 5:e1157. doi: 10.1038/cddis.2014.135.
2014
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| 25 | BRCA2, PLK1, RAD51
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| BRCA2 coordinates the activities of cell-cycle kinases to promote genome stability.
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| Yata K, Bleuyard JY, Nakato R, Ralf C, Katou Y, Schwab RA, Niedzwiedz W, Shirahige K, Esashi F.
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| Cell Rep 7(5):1547-59. doi: 10.1016/j.celrep.2014.04.023.
2014
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| 26 | PLK1, RACGAP1
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| Centralspindlin assembly and 2 phosphorylations on MgcRacGAP by Polo-like kinase 1 initiate Ect2 binding in early cytokinesis.
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| Kim H, Guo F, Brahma S, Xing Y, Burkard ME.
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| Cell Cycle 13(18):2952-61. doi: 10.4161/15384101.2014.947201.
2014
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| 27 | NCAPG2, PLK1
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| The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores.
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| Kim JH, Shim J, Ji MJ, Jung Y, Bong SM, Jang YJ, Yoon EK, Lee SJ, Kim KG, Kim YH, Lee C, Lee BI, Kim KT.
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| Nat Commun 5:4588. doi: 10.1038/ncomms5588.
2014
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| 28 | CDK1, PIN1, PLK1, SEPTIN9
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| Mitotic regulation of SEPT9 protein by cyclin-dependent kinase 1 (Cdk1) and Pin1 protein is important for the completion of cytokinesis.
|
| Estey MP, Di Ciano-Oliveira C, Froese CD, Fung KY, Steels JD, Litchfield DW, Trimble WS.
|
| J Biol Chem 288(42):30075-86. doi: 10.1074/jbc.M113.474932. Epub 2013 Aug 29. 2013
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| 29 | AURKA, BORA, BRCA1, PLK1
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| BRCA1 downregulates the kinase activity of Polo-like kinase 1 in response to replication stress.
|
| Zou J, Rezvani K, Wang H, Lee KS, Zhang D.
|
| Cell Cycle 12(14):2255-65. doi: 10.4161/cc.25349.
2013
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| 30 | AURKA, PLK1, STMN1
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| Stathmin and microtubules regulate mitotic entry in HeLa cells by controlling activation of both Aurora kinase A and Plk1.
|
| Silva VC, Cassimeris L.
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| Mol Biol Cell 24(24):3819-31. doi: 10.1091/mbc.E13-02-0108. Epub 2013 Oct 23.
2013
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| 31 | FOPNL, PLK1
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| Centrosomal protein FOR20 is essential for S-phase progression by recruiting Plk1 to centrosomes.
|
| Shen M, Cai Y, Yang Y, Yan X, Liu X, Zhou T.
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| Cell Res 23(11):1284-95. doi: 10.1038/cr.2013.127. Epub 2013 Sep 10.
2013
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| 32 | CIP2A, PLK1
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| CIP2A modulates cell-cycle progression in human cancer cells by regulating the stability and activity of Plk1.
|
| Kim JS, Kim EJ, Oh JS, Park IC, Hwang SG.
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| Cancer Res 73(22):6667-78. doi: 10.1158/0008-5472.CAN-13-0888. 2013
|
| 33 | MISP, PLK1
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| MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression.
|
| Zhu M, Settele F, Kotak S, Sanchez-Pulido L, Ehret L, Ponting CP, Gönczy P, Hoffmann I.
|
| J Cell Biol 200(6):773-87. doi: 10.1083/jcb.201207050.
2013
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| 34 | KIF2B, PLK1
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| Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation.
|
| Hood EA, Kettenbach AN, Gerber SA, Compton DA.
|
| Mol Biol Cell 23(12):2264-74. doi: 10.1091/mbc.E11-12-1013. Epub 2012 Apr 25.
2012
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| 35 | PLK1, SUGT1
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| Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment.
|
| Liu XS, Song B, Tang J, Liu W, Kuang S, Liu X.
|
| Mol Cell Biol 32(19):4053-67. doi: 10.1128/MCB.00516-12. Epub 2012 Aug 6.
2012
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| 36 | CEP55, PLK1
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| Centrosomal protein 55 (Cep55) stability is negatively regulated by p53 protein through Polo-like kinase 1 (Plk1).
|
| Chang YC, Wu CH, Yen TC, Ouyang P.
|
| J Biol Chem 287(6):4376-85. doi: 10.1074/jbc.M111.289108. Epub 2011 Dec 19.
2012
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| 37 | PLK1, TEX14
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| Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint.
|
| Mondal G, Ohashi A, Yang L, Rowley M, Couch FJ.
|
| Mol Cell 45(5):680-95. doi: 10.1016/j.molcel.2012.01.013.
2012
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| 38 | PLK1, RAD51
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| Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.
|
| Yata K, Lloyd J, Maslen S, Bleuyard JY, Skehel M, Smerdon SJ, Esashi F.
|
| Mol Cell 45(3):371-83. doi: 10.1016/j.molcel.2011.12.028.
2012
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| 39 | PLK1, PRC1
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| Plk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis.
|
| Hu CK, Ozlü N, Coughlin M, Steen JJ, Mitchison TJ.
|
| Mol Biol Cell 23(14):2702-11. doi: 10.1091/mbc.E12-01-0058. Epub 2012 May 23.
2012
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| 40 | BUB1B, PLK1
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| Integration of kinase and phosphatase activities by BUBR1 ensures formation of stable kinetochore-microtubule attachments.
|
| Suijkerbuijk SJ, Vleugel M, Teixeira A, Kops GJ.
|
| Dev Cell 23(4):745-55. doi: 10.1016/j.devcel.2012.09.005.
2012
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| 41 | NPHP1, PLK1
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| The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1.
|
| Seeger-Nukpezah T, Liebau MC, Höpker K, Lamkemeyer T, Benzing T, Golemis EA, Schermer B.
|
| PLoS One 7(6):e38838. doi: 10.1371/journal.pone.0038838. Epub 2012 Jun 11.
2012
|
| 42 | OPTN, PLK1
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| Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression.
|
| Kachaner D, Filipe J, Laplantine E, Bauch A, Bennett KL, Superti-Furga G, Israël A, Weil R.
|
| Mol Cell 45(4):553-66. doi: 10.1016/j.molcel.2011.12.030.
2012
|
| 43 | DDX39B, PLK1
|
| Plk1-mediated phosphorylation of UAP56 regulates the stability of UAP56.
|
| Xiong F, Lin Y, Han Z, Shi G, Tian L, Wu X, Zeng Q, Zhou Y, Deng J, Chen H.
|
| Mol Biol Rep 39(2):1935-42. doi: 10.1007/s11033-011-0940-x. Epub 2011 Jun 3.
2012
|
| 44 | PLK1, TCOF1
|
| Mammalian neurogenesis requires Treacle-Plk1 for precise control of spindle orientation, mitotic progression, and maintenance of neural progenitor cells.
|
| Sakai D, Dixon J, Dixon MJ, Trainor PA.
|
| PLoS Genet 8(3):e1002566. doi: 10.1371/journal.pgen.1002566. Epub 2012 Mar 29.
2012
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| 45 | AURKA, FRY, PLK1
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| Furry protein promotes aurora A-mediated Polo-like kinase 1 activation.
|
| Ikeda M, Chiba S, Ohashi K, Mizuno K.
|
| J Biol Chem 287(33):27670-81. doi: 10.1074/jbc.M112.378968. Epub 2012 Jun 29.
2012
|
| 46 | BIRC5, PLK1
|
| Survivin regulates Plk1 localization to kinetochore in mouse oocyte meiosis.
|
| Sun SC, Liu HL, Sun QY.
|
| Biochem Biophys Res Commun 421(4):797-800. doi: 10.1016/j.bbrc.2012.04.089. Epub 2012 Apr 25.
2012
|
| 47 | EIF4EBP1, PLK1
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| 4E-BP1 participates in maintaining spindle integrity and genomic stability via interacting with PLK1.
|
| Shang ZF, Yu L, Li B, Tu WZ, Wang Y, Liu XD, Guan H, Huang B, Rang WQ, Zhou PK.
|
| Cell Cycle 11(18):3463-71. doi: 10.4161/cc.21770. Epub 2012 Aug 23.
2012
|
| 48 | CDK1, CLASP2, PLK1
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| Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore-microtubule attachments.
|
| Maia AR, Garcia Z, Kabeche L, Barisic M, Maffini S, Macedo-Ribeiro S, Cheeseman IM, Compton DA, Kaverina I, Maiato H.
|
| J Cell Biol 199(2):285-301. doi: 10.1083/jcb.201203091. Epub 2012 Oct 8.
2012
|
| 49 | PLK1
|
| Polo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing.
|
| Liu D, Davydenko O, Lampson MA.
|
| J Cell Biol 198(4):491-9. doi: 10.1083/jcb.201205090.
2012
|
| 50 | PLK1, SYCP1, TEX12
|
| Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes.
|
| Jordan PW, Karppinen J, Handel MA.
|
| J Cell Sci. Nov 1;125(Pt 21):5061-72. doi: 10.1242/jcs.105015. Epub 2012 Aug 1 2012
|
| 51 | KIF2C, PLK1
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| PLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activity.
|
| Zhang L, Shao H, Huang Y, Yan F, Chu Y, Hou H, Zhu M, Fu C, Aikhionbare F, Fang G, Ding X, Yao X.
|
| J Biol Chem 286(4):3033-46. Epub 2010 Nov 15.
2011
|
| 52 | KIF11, NEK7, NEK9, PLK1
|
| Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5.
|
| Bertran MT, Sdelci S, Regué L, Avruch J, Caelles C, Roig J.
|
| EMBO J 30(13):2634-47. doi: 10.1038/emboj.2011.179.
2011
|
| 53 | CENPQ, MLF1IP, PLK1
|
| Mammalian polo-like kinase 1-dependent regulation of the PBIP1-CENP-Q complex at kinetochores.
|
| Kang YH, Park CH, Kim TS, Soung NK, Bang JK, Kim BY, Park JE, Lee KS.
|
| J Biol Chem 286(22):19744-57. Epub 2011 Mar 30.
2011
|
| 54 | CHFR, PLK1, RNF8
|
| Plk1 is negatively regulated by RNF8.
|
| Yoshioka T, Kimura M, Saio M, Era S, Okano Y.
|
| Biochem Biophys Res Commun 410(1):57-61. Epub 2011 May 24.
2011
|
| 55 | CDC25A, CDC25B, CDC25C, PLK1
|
| Study of the docking-dependent PLK1 phosphorylation of the CDC25B phosphatase.
|
| Lobjois V, Froment C, Braud E, Grimal F, Burlet-Schiltz O, Ducommun B, Bouche JP.
|
| Biochem Biophys Res Commun 410(1):87-90. Epub 2011 May 27.
2011
|
| 56 | NEDD1, PLK1
|
| Regulation of microtubule-based microtubule nucleation by mammalian polo-like kinase 1.
|
| Johmura Y, Soung NK, Park JE, Yu LR, Zhou M, Bang JK, Kim BY, Veenstra TD, Erikson RL, Lee KS.
|
| Proc Natl Acad Sci U S A 108(28):11446-51. Epub 2011 Jun 20.
2011
|
| 57 | ATXN10, PLK1
|
| Phosphorylation of Ataxin-10 by polo-like kinase 1 is required for cytokinesis.
|
| Li J, Wang J, Hou W, Jing Z, Tian C, Han Y, Liao J, Dong MQ, Xu X.
|
| Cell Cycle 10(17):2946-58. Epub 2011 Sep 1.
2011
|
| 58 | PLK1, RIOK2
|
| Phosphorylation of right open reading frame 2 (Rio2) protein kinase by polo-like kinase 1 regulates mitotic progression.
|
| Liu T, Deng M, Li J, Tong X, Wei Q, Ye X.
|
| J Biol Chem 286(42):36352-60. doi: 10.1074/jbc.M111.250175. Epub 2011 Aug 31.
2011
|
| 59 | NEK2, PLK1, PPP1CC
|
| Plk1 controls the Nek2A-PP1γ antagonism in centrosome disjunction.
|
| Mardin BR, Agircan FG, Lange C, Schiebel E.
|
| Curr Biol 21(13):1145-51. doi: 10.1016/j.cub.2011.05.047. Epub 2011 Jun 30.
2011
|
| 60 | PCNT, PLK1
|
| PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis.
|
| Lee K, Rhee K.
|
| J Cell Biol 195(7):1093-101. doi: 10.1083/jcb.201106093. Epub 2011 Dec 19.
2011
|
| 61 | ORC2, PLK1
|
| Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stress.
|
| Song B, Liu XS, Davis K, Liu X.
|
| Mol Cell Biol 31(23):4844-56. doi: 10.1128/MCB.06110-11. Epub 2011 Sep 26.
2011
|
| 62 | HAUS8, NEDD1, PLK1
|
| Regulation of microtubule-based microtubule nucleation by mammalian polo-like kinase 1.
|
| Johmura Y, Soung NK, Park JE, Yu LR, Zhou M, Bang JK, Kim BY, Veenstra TD, Erikson RL, Lee KS.
|
| Proc Natl Acad Sci U S A 108(28):11446-51. doi: 10.1073/pnas.1106223108. Epub 2011 Jun 20.
2011
|
| 63 | AURKA, CDK1, PLK1
|
| Cdk1 activity is required for mitotic activation of aurora A during G2/M transition of human cells.
|
| Van Horn RD, Chu S, Fan L, Yin T, Du J, Beckmann R, Mader M, Zhu G, Toth J, Blanchard K, Ye XS.
|
| J Biol Chem 285(28):21849-57. Epub 2010 May 5.PMID: 20444701 2010
|
| 64 | DCTN1, PLK1
|
| Polo-like kinase 1 phosphorylation of p150Glued facilitates nuclear envelope breakdown during prophase.
|
| Li H, Liu XS, Yang X, Song B, Wang Y, Liu X.
|
| Proc Natl Acad Sci U S A 107(33):14633-8. Epub 2010 Aug 2.PMID: 20679239 2010
|
| 65 | BIRC5, PLK1
|
| Liaisons between survivin and Plk1 during cell division and cell death.
|
| Colnaghi R, Wheatley SP.
|
| J Biol Chem 285(29):22592-604. Epub 2010 Apr 28.PMID: 20427271 2010
|
| 66 | CNTROB, PLK1
|
| Centrobin/NIP2 is a microtubule stabilizer whose activity is enhanced by PLK1 phosphorylation during mitosis.
|
| Lee J, Jeong Y, Jeong S, Rhee K.
|
| J Biol Chem 285(33):25476-84. Epub 2010 May 29.PMID: 20511645 2010
|
| 67 | MAP9, PLK1
|
| Plk1 regulates both ASAP localization and its role in spindle pole integrity.
|
| Eot-Houllier G, Venoux M, Vidal-Eychenié S, Hoang MT, Giorgi D, Rouquier S.
|
| J Biol Chem 285(38):29556-68. Epub 2010 Jul 8.
2010
|
| 68 | CLIP1, CSNK2A1, PLK1
|
| Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore-microtubule attachments.
|
| Li H, Liu XS, Yang X, Wang Y, Wang Y, Turner JR, Liu X.
|
| EMBO J 29(17):2953-65. Epub 2010 Jul 27.
2010
|
| 69 | PLK1, TOPORS
|
| Plk1 phosphorylation of Topors is involved in its degradation.
|
| Yang X, Li H, Deng A, Liu X.
|
| Mol Biol Rep 37(6):3023-8. Epub 2009 Oct 11. 2010
|
| 70 | DVL2, PLK1
|
| Dishevelled, a Wnt signalling component, is involved in mitotic progression in cooperation with Plk1.
|
| Kikuchi K, Niikura Y, Kitagawa K, Kikuchi A.
|
| EMBO J 29(20):3470-83. Epub 2010 Sep 7.
2010
|
| 71 | GORASP1, PLK1
|
| Mitotic inhibition of GRASP65 organelle tethering involves Polo-like kinase 1 (PLK1) phosphorylation proximate to an internal PDZ ligand.
|
| Sengupta D, Linstedt AD.
|
| J Biol Chem 285(51):39994-40003. Epub 2010 Oct 11.
2010
|
| 72 | ERCC6L, PLK1
|
| PICH and cotargeted Plk1 coordinately maintain prometaphase chromosome arm architecture.
|
| Kurasawa Y, Yu-Lee LY.
|
| Mol Biol Cell 21(7):1188-99. Epub 2010 Feb 3.
2010
|
| 73 | CEP55, PLK1
|
| Plk1 negatively regulates Cep55 recruitment to the midbody to ensure orderly abscission.
|
| Bastos RN, Barr FA.
|
| J Cell Biol 191(4):751-60. doi: 10.1083/jcb.201008108.
2010
|
| 74 | BCL2L1, PLK1
|
| Polo-like kinase 1 phosphorylates and regulates Bcl-x(L) during pironetin-induced apoptosis.
|
| Tamura Y, Simizu S, Muroi M, Takagi S, Kawatani M, Watanabe N, Osada H.
|
| Oncogene 28(1):107-16. Epub 2008 Sep 29.
2009
|
| 75 | CDC25C, CDK1, MKLP2, MYT1, PLK1, PLK2, PLK3, PLK4, PPA2, PRC1, SGOL1, WEE1
|
| Polo-like kinases: conservation and divergence in their functions and regulation.
|
| Archambault V, Glover DM.
|
| Nat Rev Mol Cell Biol 10(4):265-75. Review. Erratum in: Nat Rev Mol Cell Biol. 2009 May;10(5):364. 2009
|
| 76 | PLK1, RACGAP1
|
| Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.
|
| Burkard ME, Maciejowski J, Rodriguez-Bravo V, Repka M, Lowery DM, Clauser KR, Zhang C, Shokat KM, Carr SA, Yaffe MB, Jallepalli PV.
|
| PLoS Biol 7(5):e1000111. Epub 2009 May 26.
2009
|
| 77 | PLK1
|
| Page of 6Next 1: Association of spindle midzone particles with polo-like kinase 1 during meiosis in mouse and human oocytes.
|
| Otsuki J, Nagai Y, Chiba K.
|
| Reprod Biomed Online 18(4):522-8.
2009
|
| 78 | FBXO5, PLK1
|
| Polo-like kinase 1 depletion induces DNA damage in early S prior to caspase activation.
|
| Yim H, Erikson RL.
|
| Mol Cell Biol 29(10):2609-21. Epub 2009 Mar 16.
2009
|
| 79 | BUB1B, PLK1
|
| BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells.
|
| Izumi H, Matsumoto Y, Ikeuchi T, Saya H, Kajii T, Matsuura S.
|
| Oncogene 28(31):2806-20. Epub 2009 Jun 8.
2009
|
| 80 | MAVS, PLK1
|
| Polo-like kinase 1 (PLK1) regulates interferon (IFN) induction by MAVS.
|
| Vitour D, Dabo S, Ahmadi Pour M, Vilasco M, Vidalain PO, Jacob Y, Mezel-Lemoine M, Paz S, Arguello M, Lin R, Tangy F, Hiscott J, Meurs EF.
|
| J Biol Chem 284(33):21797-809. Epub 2009 Jun 22.PMID: 19546225 2009
|
| 81 | PLK1, TP63
|
| Plk1 regulates liver tumor cell death by phosphorylation of TAp63.
|
| Komatsu S, Takenobu H, Ozaki T, Ando K, Koida N, Suenaga Y, Ichikawa T, Hishiki T, Chiba T, Iwama A, Yoshida H, Ohnuma N, Nakagawara A, Kamijo T.
|
| Oncogene 28(41):3631-41. Epub 2009 Aug 10.
2009
|
| 82 | HAUS6, PLK1
|
| FAM29A, a target of Plk1 regulation, controls the partitioning of NEDD1 between the mitotic spindle and the centrosomes.
|
| Zhu H, Fang K, Fang G.
|
| J Cell Sci 122(Pt 15):2750-9. Epub 2009 Jul 13.PMID: 19596795 2009
|
| 83 | PLK1, TOPORS
|
| Plk1-mediated phosphorylation of Topors regulates p53 stability.
|
| Yang X, Li H, Zhou Z, Wang WH, Deng A, Andrisani O, Liu X.
|
| J Biol Chem 284(28):18588-92. Epub 2009 May 27.
2009
|
| 84 | PLK1, TUBG1
|
| Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components.
|
| Haren L, Stearns T, Lüders J.
|
| PLoS One 4(6):e5976.
2009
|
| 85 | CDK1, NEDD1, PLK1, TUBG1
|
| Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome.
|
| Zhang X, Chen Q, Feng J, Hou J, Yang F, Liu J, Jiang Q, Zhang C.
|
| J Cell Sci 122(Pt 13):2240-51. Epub 2009 Jun 9.
2009
|
| 86 | AURKA, KIF2A, PLK1
|
| Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a.
|
| Jang CY, Coppinger JA, Seki A, Yates JR 3rd, Fang G.
|
| J Cell Sci 122(Pt 9):1334-41. doi: 10.1242/jcs.044321. Epub 2009 Apr 7.
2009
|
| 87 | CEP55, PLK1
|
| Cep55 stabilization is required for normal execution of cytokinesis.
|
| van der Horst A, Simmons J, Khanna KK.
|
| Cell Cycle 8(22):3742-9. Epub 2009 Nov 10.
2009
|
| 88 | AURKA, BORA, PLK1
|
| Aurora-A and hBora join the game of Polo.
|
| Macurek L, Lindqvist A, Medema RH.
|
| Cancer Res 69(11):4555-8. doi: 10.1158/0008-5472.CAN-09-0142. Review.
2009
|
| 89 | KAT7, PLK1
|
| Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing.
|
| Wu ZQ, Liu X.
|
| Proc Natl Acad Sci U S A 105(6):1919-24. Epub 2008 Feb 4. 2008
|
| 90 | PLK1, BTRC, BORA
|
| Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression.
|
| Seki A, Coppinger JA, Du H, Jang CY, Yates JR 3rd, Fang G.
|
| J Cell Biol 181(1):65-78. Epub 2008 Mar 31. 2008
|
| 91 | PLK1
|
| Plx1 is required for chromosomal DNA replication under stressful conditions.
|
| Trenz K, Errico A, Costanzo V.
|
| EMBO J 27(6):876-85. Epub 2008 Feb 28. 2008
|
| 92 | AURKA, PLK1
|
| Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery.
|
| Macůrek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SS, Yaffe MB, Medema RH.
|
| Nature 455(7209):119-23. Epub 2008 Jul 9.
2008
|
| 93 | MAD1L1, MAD2L1, PLK1
|
| Requirements for protein phosphorylation and the kinase activity of polo-like kinase 1 (Plk1) for the kinetochore function of mitotic arrest deficiency protein 1 (Mad1).
|
| Chi YH, Haller K, Ward MD, Semmes OJ, Li Y, Jeang KT.
|
| J Biol Chem 283(51):35834-44. Epub 2008 Oct 15.
2008
|
| 94 | PLEKHG6, PLK1, RHOA
|
| Phosphorylation of MyoGEF on Thr-574 by Plk1 promotes MyoGEF localization to the central spindle.
|
| Asiedu M, Wu D, Matsumura F, Wei Q.
|
| J Biol Chem 283(42):28392-400. Epub 2008 Aug 11.PMID: 18694934 2008
|
| 95 | PLK1
|
| Polo-like kinase 1 as a new target for non-Hodgkin's lymphoma treatment.
|
| Liu L, Zhang M, Zou P.
|
| Oncology 74(1-2):96-103. Epub 2008 Jun 12.PMID: 18547964 2008
|
| 96 | PLK1, PLK2, PLK3
|
| Polo-box domains confer target specificity to the Polo-like kinase family.
|
| van de Weerdt BC, Littler DR, Klompmaker R, Huseinovic A, Fish A, Perrakis A, Medema RH.
|
| Biochim Biophys Acta 1783(6):1015-22. Epub 2008 Mar 5.PMID: 18359294 2008
|
| 97 | ERCC6L, PLK1
|
| Targeting Plk1 to chromosome arms and regulating chromosome compaction by the PICH ATPase.
|
| Leng M, Bessuso D, Jung SY, Wang Y, Qin J.
|
| Cell Cycle 7(10):1480-9. Epub 2008 Mar 16.
2008
|
| 98 | AURKA, BORA, PLK1
|
| Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery.
|
| Macůrek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SS, Yaffe MB, Medema RH.
|
| Nature 455(7209):119-23. doi: 10.1038/nature07185. Epub 2008 Jul 9.
2008
|
| 99 | BORA, PLK1
|
| Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora.
|
| Chan EH, Santamaria A, Silljé HH, Nigg EA.
|
| Chromosoma 117(5):457-69. doi: 10.1007/s00412-008-0165-5. Epub 2008 Jun 3.
2008
|
| 100 | PLK1, CDC25C
|
| Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization.
|
| Garcia-Alvarez B, de Carcer G, Ibanez S, Bragado-Nilsson E, Montoya G.
|
| Proc Natl Acad Sci U S A 104(9):3107-12. Epub 2007 Feb 16. 2007
|
| 101 | PLK1
|
| Structure of the catalytic domain of human polo-like kinase 1.
|
| Kothe M, Kohls D, Low S, Coli R, Cheng AC, Jacques SL, Johnson TL, Lewis C, Loh C, Nonomiya J, Sheils AL, Verdries KA, Wynn TA, Kuhn C, Ding YH.
|
| Biochemistry 46(20):5960-71. Epub 2007 Apr 27.
2007
|
| 102 | TSC1, TSC2, PLK1
|
| Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner.
|
| Astrinidis A, Senapedis W, Henske EP.
|
| Hum Mol Genet 15(2):287-97. Epub 2005 Dec 8. 2006
|
| 103 | BUB1, PLK1
|
| Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1.
|
| Qi W, Tang Z, Yu H.
|
| Mol Biol Cell 17(8):3705-16. Epub 2006 Jun 7. 2006
|
| 104 | PLK1, TP53
|
| Polo-like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation.
|
| Chen J, Dai G, Wang YQ, Wang S, Pan FY, Xue B, Zhao DH, Li CJ.
|
| FEBS Lett 580(15):3624-30. Epub 2006 May 30. 2006
|
| 105 | PLK1, BIRC5
|
| Polo-like kinase and survivin are esophageal tumor-specific promoters.
|
| Sato F, Abraham JM, Yin J, Kan T, Ito T, Mori Y, Hamilton JP, Jin Z, Cheng Y, Paun B, Berki AT, Wang S, Shimada Y, Meltzer SJ.
|
| Biochem Biophys Res Commun 342(2):465-71. Epub 2006 Feb 9. 2006
|
| 106 | NUDC, PLK1
|
| NudC is required for Plk1 targeting to the kinetochore and chromosome congression.
|
| Nishino M, Kurasawa Y, Evans R, Lin SH, Brinkley BR, Yu-Lee LY.
|
| Curr Biol 16(14):1414-21. 2006
|
| 107 | PLK1
|
| Overexpression of polo-like kinase 1 (PLK1) and chromosomal instability in bladder cancer.
|
| Yamamoto Y, Matsuyama H, Kawauchi S, Matsumoto H, Nagao K, Ohmi C, Sakano S, Furuya T, Oga A, Naito K, Sasaki K.
|
| Oncology 70(3):231-7. Epub 2006 Jul 6. 2006
|
| 108 | CLSPN, PLK1
|
| Claspin: timing the cell cycle arrest when the genome is damaged.
|
| Freire R, van Vugt MA, Mamely I, Medema RH.
|
| Cell Cycle 5(24):2831-4. Epub 2006 Dec 15. Review.
2006
|
| 109 | KIZ, PLK1
|
| The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity.
|
| Oshimori N, Ohsugi M, Yamamoto T.
|
| Nat Cell Biol. Oct;8(10):1095-101. doi: 10.1038/ncb1474. Epub 2006 Sep 17. 2006
|
| 110 | PLK1, TCP1
|
| CCT chaperonin complex is required for the biogenesis of functional Plk1.
|
| Liu X, Lin CY, Lei M, Yan S, Zhou T, Erikson RL.
|
| Mol Cell Biol 25(12):4993-5010. 2005
|
| 111 | NIN, NINL, PLK1
|
| Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome.
|
| Casenghi M, Barr FA, Nigg EA.
|
| J Cell Sci 118(Pt 21):5101-8. 2005
|
| 112 | ADI1, AMDHD1, C14orf68, PID1, PLK1, PLK1, UROC, ZNF513
|
| Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.
|
| Yamada S, Ohira M, Horie H, Ando K, Takayasu H, Suzuki Y, Sugano S, Hirata T, Goto T, Matsunaga T, Hiyama E, Hayashi Y, Ando H, Suita S, Kaneko M, Sasaki F, Hashizume K, Ohnuma N, Nakagawara A.
|
| Oncogene 23(35):5901-11. 2004
|
| 113 | PLK1
|
| The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain.
|
| Elia AE, Rellos P, Haire LF, Chao JW, Ivins FJ, Hoepker K, Mohammad D, Cantley LC, Smerdon SJ, Yaffe MB.
|
| Cell 115(1):83-95. 2003
|
| 114 | PKMYT1, PLK1
|
| Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate.
|
| Nakajima H, Toyoshima-Morimoto F, Taniguchi E, Nishida E.
|
| J Biol Chem 278(28):25277-80. Epub 2003 May 08. 2003
|
| 115 | PLK1
|
| Polo-like kinase 1 (PLK1) is overexpressed in primary colorectal cancers.
|
| Takahashi T, Sano B, Nagata T, Kato H, Sugiyama Y, Kunieda K, Kimura M, Okano Y, Saji S.
|
| Cancer Sci 94(2):148-52. 2003
|
| 116 | PLK1, SLK, STK10
|
| Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue.
|
| Walter SA, Cutler RE Jr, Martinez R, Gishizky M, Hill RJ.
|
| J Biol Chem 278(20):18221-8. Epub 2003 Mar 13.
2003
|
| 117 | PLK1
|
| Functional studies on the role of the C-terminal domain of mammalian polo-like kinase.
|
| Jang YJ, Lin CY, Ma S, Erikson RL.
|
| Proc Natl Acad Sci U S A 99(4):1984-9. 2002
|
| 118 | PLK1
|
| Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA.
|
| Liu X, Erikson RL.
|
| Proc Natl Acad Sci U S A 99(13):8672-6. 2002
|
| 119 | PLK1
|
| Downregulation of human polo-like kinase activity by antisense oligonucleotides induces growth inhibition in cancer cells.
|
| Spankuch-Schmitt B, Wolf G, Solbach C, Loibl S, Knecht R, Stegmuller M, von Minckwitz G, Kaufmann M, Strebhardt K.
|
| Oncogene 21(20):3162-71. 2002
|
| 120 | CCNB1, PLK1
|
| Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1.
|
| Yuan J, Eckerdt F, Bereiter-Hahn J, Kurunci-Csacsko E, Kaufmann M, Strebhardt K.
|
| Oncogene 21(54):8282-92. 2002
|
| 121 | PLK1
|
| Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase.
|
| Toyoshima-Morimoto F, Taniguchi E, Shinya N, Iwamatsu A, Nishida E.
|
| Nature 410(6825):215-20. 2001
|
| 122 | PLK1
|
| Malignant transformation of mammalian cells initiated by constitutive expression of the polo-like kinase.
|
| Smith MR, Wilson ML, Hamanaka R, Chase D, Kung H, Longo DL, Ferris DK.
|
| Biochem Biophys Res Commun 234(2):397-405. 1997
|
| 123 | PLK1
|
| Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors.
|
| Holtrich U, Wolf G, Brauninger A, Karn T, Bohme B, Rubsamen-Waigmann H, Strebhardt K.
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| Proc Natl Acad Sci U S A 91(5):1736-40. 1994
|
| 124 | PLK1
|
| Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5.
|
| Golsteyn RM, Schultz SJ, Bartek J, Ziemiecki A, Ried T, Nigg EA.
|
| J Cell Sci 107 ( Pt 6):1509-17. 1994
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