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FLASH GENE
Symbol PLAUR contributors: mct/npt/pgu - updated : 30-11-2016
HGNC name plasminogen activator, urokinase receptor
HGNC id 9053
Location 19q13.2      Physical location : 44.150.247 - 44.174.502
Synonym name
  • monocyte activation antigen Mo3
  • u-plasminogen activator receptor form 2
  • CD87 antigen
  • Synonym symbol(s) CD87, UPAR, URKR, MO3
    DNA
    TYPE functioning gene
    STRUCTURE 24.25 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    MAPPING cloned Y linked Y status confirmed
    Physical map
    PSG5 19q13.2 pregnancy specific beta-1-glycoprotein 5 PSG4 19q13.2 pregnancy specific beta-1-glycoprotein 4 CEACAMP10 19q13.2 carcinoembryonic antigen-related cell adhesion molecule pseudogene 10 PSG9 19q13.2 pregnancy specific beta-1-glycoprotein 9 CEACAMP11 19q13.2 carcinoembryonic antigen-related cell adhesion molecule pseudogene 11 CEACAMP4 19q13.2 carcinoembryonic antigen-related cell adhesion molecule pseudogene 4 PRV1 19q13.2 carcinoembryonic antigen-related cell adhesion molecule pseudogene 4 LOC388547 19 similar to polycythemia rubra vera 1; cell surface receptor MGC4766 19q13.32 testis-specific protein TES101RP C4.4A 19q13.32 GPI-anchored metastasis-associated protein homolog LOC388548 19 similar to LL5 beta LOC284345 19q13.32 similar to LL5 beta ETHE1 LOC284346 19q13.32 hypothetical protein LOC284346 XRCC1 19q13.2 X-ray repair complementing defective repair in Chinese hamster cells 1 LOC390940 19 similar to R28379_1 LOC126298 19q13.32 similar to FKSG27 MGC2508 19q13.32 hypothetical protein MGC2508 MGC51082 19q13.32 hypothetical protein MGC51082 TSLL2 19q13.32 hypothetical protein MGC51082 PLAUR 19q13.2 plasminogen activator, urokinase receptor R30953_1 19q13.32 hypothetical protein R30953_1 FLJ12886 19q13.32 hypothetical protein FLJ12886 KCNN4 19q13.2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 FLJ30469 19q13.32 hypothetical protein FLJ30469 ZNF283 19q13.32 zinc finger protein 283 ZNF404 19q13.32 zinc finger protein 404 ZNF45 19q13.2 zinc finger protein 45 (a Kruppel-associated box (KRAB) domain polypeptide) ZNF221 19q13.2 zinc finger protein 221 ZNF155 19q13.2-q13.32 zinc finger protein 155 (pHZ-96) ZNF230 19q13.2 zinc finger protein 230 ZNF222 19q13.2 zinc finger protein 222 ZNF223 19q13.2 zinc finger protein 223
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1437 - 281 - 1992 1316922
    soluble and secreted
    7 - 1548 37 335 - 1992 1316922
    attached to the membrane by a GPI-anchor
    6 - 1413 - 290 - 1992 1316922
    lacks one of three LU (Ly-6 antigen/uPA receptor-like) domains
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three UPAR/LY6 domains
  • a predicted signal peptide of 22 AAs
  • a hydrophobic C-terminal portion that is probably cleaved during formation of the GPI linkage
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor , receptor membrane
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    basic FUNCTION
  • playing a role in localizing and promoting plasmin formation
  • contributes to the migratory potential of macrophages, a key event in atherosclerosis
  • playing a physiological role in the regulation of kidney permeability
  • is a non-integrin vitronectin (VTN) cell adhesion receptor linked to the plasma membrane by a glycolipid anchor
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • crucial component of the extracellular plasminogen proteolysis system
  • FOXP2-SRPX2/PLAUR network provides exciting insights into molecular pathways underlying speech-related disorders
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly interact with SRPX2, and the SRPX2/PLAUR ligand–receptor interaction showed quantitative modification caused by a pathogenic mutation of SRPX2
  • functional link between FOXP2 and both the SRPX2 and the PLAUR genes
  • SERPINB5 physically associates with both PLAUR and ITGB1, thus producing a complex that regulates both cell motility and adhesion
  • importance of VTN and its interaction with PLAUR in tumor growth
  • interactions between PLAUR and HSPA4/DNAJB6 having functions in cell adhesion and migration that may provide more understanding of the roles in regulating cancer metastasis
  • cell & other
    REGULATION
    repressed by FOXP2 (down-regulates both the SRPX2 and the PLAUR genes and this transcriptional regulation is lost when FOXP2 bears a pathogenic p.R553H mutation that is known to cause DVD (developmental verbal dyspraxia)
    Other regulation of urokinase receptor expression by protein tyrosine phosphatases
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in diffuse type gastric carcinoma
    constitutional       loss of function
    necessary for myofibroblast differentiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS