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FLASH GENE

Symbol

PLA2G7

contributors: mct/npt - updated : 14-06-2008

HGNC name	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
HGNC id	9040

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p21.2-p12      Physical location : 46.672.053 - 46.703.430
Synonym name	platelet-activating factor acetylhydrolase
	PAF 2-acylhydrolase
	LDL-associated phospholipase A2
	2-acetyl-1-alkylglycerophosphocholine esterase
Synonym symbol(s)	PAFAH, LDL-PLA2, LDL-PLA
EC.number	3.1.1.47

DNA

TYPE	functioning gene
STRUCTURE	30.00 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 12 - 1880 - 440 - Sutton (2008)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue         pharynx       highly Lymphoid/Immune spleen       highly Reproductive female system placenta     highly   male system prostate       Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic plasma

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune macrophage

cell lineage
cell lines
fluid/secretion	blood

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a unique sequence motif Gly-X-Ser-X-Gly commonly found in lipases

HOMOLOGY

Homologene

FAMILY	AB hydrolase superfamily
	lipase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm

basic FUNCTION	LDL-associated phospholipase A2 group VII, serine dependent, involved in the oxidative modification of low density lipoproteins
	platelet activating factor acetylhydrolase plasma
	inhibiting the proinflammatory properties of PAH

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

associating with high and low density lipoproteins (HDL and LDL)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

mutations V279 are a risk factor for stroke in Japanese population suceptibility to atopy and asthma to coronary artery disease

Variant & Polymorphism SNP , other	I198T
	A379V protecting against coronary artery disease
	alleles thr-198 and val-379 are associated with atopy and asthma
	SNP increasing the risk of coronary artery disease

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS