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FLASH GENE
Symbol PIWIL1 contributors: mct - updated : 16-02-2018
HGNC name piwi-like 1 (Drosophila)
HGNC id 9007
Location 12q24.33      Physical location : 130.822.432 - 130.856.877
Synonym name
  • piwi homolog
  • piwi-like 1
  • Synonym symbol(s) HIWI, PIW1, MIWI
    DNA
    TYPE functioning gene
    STRUCTURE 34.26 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 3591 98.47 861 - 2003 12906857
    - - 2797 - 829 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid
    Reproductivespermatocyte
    cell lineage
    cell lines germ cells lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text primitive neurectoderm, fetal eye
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • multiple arginine-glycine (RG) and arginine-alanine (RA) repeats at the N-terminus, and methylation of these arginine sites is important for recruiting the Tudor domain-containing (TDRD) group of germ-line-enriched Tudor domain proteins
  • a conserved 43 AAs piwi box
  • one PAZ domain
  • HOMOLOGY
    interspecies homolog to Drosophila piwi
    homolog to murine Piwil1
    Homologene
    FAMILY
  • argonaute family
  • PIWI subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    text nuclear import of Ago proteins in cells influenced by IPO8
    basic FUNCTION
  • playing an important role in the eukaryotic peptide chain initiation process
  • play pivotal roles in transposon silencing during gametogenesis
  • essential role in the formation of chromatoid bodies
  • involved in stem cell self-renewal, and having a role in prognostic factor of soft-tissue sarcoma
  • associating with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis
  • required for the stability of its target mRNAs as well as for the integrity of the chromatoid body
  • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physically interacts with KIF17
  • direct physical interaction of PIWIL1 and PIWIL2 with TDRD6
  • formation of complexes between PIWIL1, PIWIL2 and TDRD1 is critical for the integrated subcellular localizations of these proteins, and is presumably essential for spermatogenesis
  • interacting with MOV10L1 (interacts also with heat shock 70-kDa protein 2 (HSPA2), a testis-enriched chaperone expressed in pachytene spermatocytes, and essential for male fertility)
  • TDRKH partners with PIWIL1 and PIWIL4 via symmetrically dimethylated arginine residues in PIWIL1 and PIWIL4
  • cell & other
  • cellular binding partners of miRNAs as well as other small RNAs and are therefore key components of miRNP
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in seminomas
    tumoral     --over  
    can increase the risk of tumour-related death in male ductal adenocarcinoma of the pancreas patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • PIWIL1 expression may be considered a potential prognostic biomarker for resectable pancreatic cancer and may serve to guide subsequent adjuvant treatment decisions
  • PIWIL1, PIWIL2, and PIWIL4 are potential prognostic biomarkers in patients with renal cell carcinoma
  • Therapy target
    ANIMAL & CELL MODELS