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FLASH GENE

Symbol

PIWIL1

contributors: mct - updated : 16-02-2018

HGNC name	piwi-like 1 (Drosophila)
HGNC id	9007

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q24.33      Physical location : 130.822.432 - 130.856.877
Synonym name	piwi homolog
	piwi-like 1
Synonym symbol(s)	HIWI, PIW1, MIWI

DNA

TYPE	functioning gene
STRUCTURE	34.26 kb     21 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004764 21 - 3591 NP_004755 98.47 861 - 2003 12906857 NM_001190971 - - 2797 NP_001177900 - 829 - -

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Reproductive spermatid Reproductive spermatocyte

cell lineage
cell lines	germ cells lines
fluid/secretion

at STAGE

physiological period

embryo, fetal

Text	primitive neurectoderm, fetal eye

PROTEIN

PHYSICAL PROPERTIES		basic
STRUCTURE

motifs/domains	multiple arginine-glycine (RG) and arginine-alanine (RA) repeats at the N-terminus, and methylation of these arginine sites is important for recruiting the Tudor domain-containing (TDRD) group of germ-line-enriched Tudor domain proteins
	a conserved 43 AAs piwi box
	one PAZ domain

HOMOLOGY

interspecies	homolog to Drosophila piwi
	homolog to murine Piwil1

Homologene

FAMILY	argonaute family
	PIWI subfamily

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,nucleus
text	nuclear import of Ago proteins in cells influenced by IPO8

basic FUNCTION	playing an important role in the eukaryotic peptide chain initiation process
	play pivotal roles in transposon silencing during gametogenesis
	essential role in the formation of chromatoid bodies
	involved in stem cell self-renewal, and having a role in prognostic factor of soft-tissue sarcoma
	associating with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis
	required for the stability of its target mRNAs as well as for the integrity of the chromatoid body

CELLULAR PROCESS	cell cycle, division, mitosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	physically interacts with KIF17
	direct physical interaction of PIWIL1 and PIWIL2 with TDRD6
	formation of complexes between PIWIL1, PIWIL2 and TDRD1 is critical for the integrated subcellular localizations of these proteins, and is presumably essential for spermatogenesis
	interacting with MOV10L1 (interacts also with heat shock 70-kDa protein 2 (HSPA2), a testis-enriched chaperone expressed in pachytene spermatocytes, and essential for male fertility)
	TDRKH partners with PIWIL1 and PIWIL4 via symmetrically dimethylated arginine residues in PIWIL1 and PIWIL4

cell & other

cellular binding partners of miRNAs as well as other small RNAs and are therefore key components of miRNP

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in seminomas tumoral     --over   can increase the risk of tumour-related death in male ductal adenocarcinoma of the pancreas patients

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	PIWIL1 expression may be considered a potential prognostic biomarker for resectable pancreatic cancer and may serve to guide subsequent adjuvant treatment decisions
	PIWIL1, PIWIL2, and PIWIL4 are potential prognostic biomarkers in patients with renal cell carcinoma
Therapy target

ANIMAL & CELL MODELS