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FLASH GENE
Symbol PIWIL1 contributors: mct - updated : 16-02-2018
HGNC name piwi-like 1 (Drosophila)
HGNC id 9007
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • multiple arginine-glycine (RG) and arginine-alanine (RA) repeats at the N-terminus, and methylation of these arginine sites is important for recruiting the Tudor domain-containing (TDRD) group of germ-line-enriched Tudor domain proteins
  • a conserved 43 AAs piwi box
  • one PAZ domain
  • HOMOLOGY
    interspecies homolog to Drosophila piwi
    homolog to murine Piwil1
    Homologene
    FAMILY
  • argonaute family
  • PIWI subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    text nuclear import of Ago proteins in cells influenced by IPO8
    basic FUNCTION
  • playing an important role in the eukaryotic peptide chain initiation process
  • play pivotal roles in transposon silencing during gametogenesis
  • essential role in the formation of chromatoid bodies
  • involved in stem cell self-renewal, and having a role in prognostic factor of soft-tissue sarcoma
  • associating with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis
  • required for the stability of its target mRNAs as well as for the integrity of the chromatoid body
  • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physically interacts with KIF17
  • direct physical interaction of PIWIL1 and PIWIL2 with TDRD6
  • formation of complexes between PIWIL1, PIWIL2 and TDRD1 is critical for the integrated subcellular localizations of these proteins, and is presumably essential for spermatogenesis
  • interacting with MOV10L1 (interacts also with heat shock 70-kDa protein 2 (HSPA2), a testis-enriched chaperone expressed in pachytene spermatocytes, and essential for male fertility)
  • TDRKH partners with PIWIL1 and PIWIL4 via symmetrically dimethylated arginine residues in PIWIL1 and PIWIL4
  • cell & other
  • cellular binding partners of miRNAs as well as other small RNAs and are therefore key components of miRNP
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in seminomas
    tumoral     --over  
    can increase the risk of tumour-related death in male ductal adenocarcinoma of the pancreas patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • PIWIL1 expression may be considered a potential prognostic biomarker for resectable pancreatic cancer and may serve to guide subsequent adjuvant treatment decisions
  • PIWIL1, PIWIL2, and PIWIL4 are potential prognostic biomarkers in patients with renal cell carcinoma
  • Therapy target
    ANIMAL & CELL MODELS