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FLASH GENE

Symbol

PIM2

contributors: mct - updated : 06-03-2015

HGNC name	pim-2 oncogene
HGNC id	8987

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	Xp11.23      Physical location : 48.770.460 - 48.776.413
Synonym name	proto-oncogene PIM-2 (serine threonine kinase)
	serine/threonine protein kinase PIM-2
EC.number	2.7.1.37/ 2.7.11.1

DNA

TYPE	functioning gene
STRUCTURE	5.95 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	pter - DXS1061 ,DXS1214 - DXS997 - DXS1058 ,DXS993 - DXS1201 ,DXS8026 - PIM2 - GATA1 - DXS1039 - qter
Authors	GeneMap (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006875 6 - 2234 NP_006866 34 311 - 2012 22506047 short has differential nuclear and cytoplasmic forms in all tested cell lines, suggesting a possible role for the balance between these forms for PIM2 function large - - 5000 41 - leukemia and lymphoma cell lines, testis (primary germ cells), small intestine, colon and colorectal adenocarcinoma cells 2012 22506047

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Digestive intestine small intestine         intestine large intestine colon     Endocrine pancreas         Reproductive male system testis         male system prostate       Respiratory lung         Skeleton appendicular skeleton         Homo sapiens Adult Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood/Hematopoietic bone marrow       Connective cartilage       Homo sapiens Adult

cells

System Cell Pubmed Species Stage Rna symbol not specific chondrocyte Homo sapiens Adult Reproductive germ cell

cell lineage	hematopoietic cell lineage
cell lines	leukemia and lymphoma cell lines,colorectal adenocarcinoma cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to murine Pim-2 oncogene
	homolog to C.elegans prk-2

Homologene

FAMILY	SER/THR family of protein kinases
	PIM family, related to camodulin-calcium family of protein-kinases

CATEGORY

enzyme , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	serine threonine kinase
	having a role in proliferating cells as well as during meiosis
	protected chondrocytes from rapamycin sensitized (TOR inhibited) cell death
	regulates a new intermediate stage in the differentiation pathway, the induction of autophagy
	PIM1 and PIM2 play a key role in the v-Abl transformation, possibly via participating in modulation of SOCS1 and via regulating the apoptotic signaling
	promote cell cycle progression and tumorigenesis by down-regulating CDKN1B expression at both transcriptional and posttranslational levels
	PIM2 promotes liver tumorigenesis induction through mediating survival and preventing apoptosis of liver cell
	involved in cell survival and cell proliferation
	novel anti-apoptotic mediator in myeloma cells
	can function as a potent survival factor, but it can, under certain circumstances, exhibit pro-apoptotic effects as well
	PIM1, PIM2, PIM3 have been implicated in the regulation of apoptosis, metabolism, cell cycle, and homing and migration, which has led to the postulation of these proteins as interesting targets for anticancer drug discovery

CELLULAR PROCESS	cell cycle,division,meiosis
	cell life, proliferation/growth
	cell life, antiapoptosis
	protein, post translation

PHYSIOLOGICAL PROCESS

text	control of cell proliferation
	male meiosis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein	regulating the stability of SOCS1 protein
	phosphorylating the pro-apoptotic protein BAD on serine 112, which accounts in part for its ability to reverse Bad-induced cell death
	promoted expression and organization of autophagic proteins MAP1LC3A, and Beclin-1 and enhanced lysosomal acidification
	phosphorylates the cell cycle inhibitor CDKN1A on Thr145
	may inhibit the apoptosis of Prostate cancer cells (PCA) through phosphorylating EIF4B, thus promoting the tumorigenesis of PCA

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in multiple B-cell lymphoma types, associated with an aggressive clinical course tumoral     --over   in Prostate cancer cell lines and tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   PIM2 kinase inhibition is a rational approach in DLBCL treatment cancer hemopathy   new target for multiple myeloma treatment cancer reproductive breast PIM2-USP27X-MYC signaling axis is a new potential target for breast cancer treatment

ANIMAL & CELL MODELS

compound Pim knockhout mice show a profound reduction of body size and non efficient proliferation of peripheral T lymphocytes