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FLASH GENE
Symbol PIM2 contributors: mct - updated : 06-03-2013
HGNC name pim-2 oncogene
HGNC id 8987
Location Xp11.23      Physical location : 48.770.460 - 48.776.413
Synonym name
  • proto-oncogene PIM-2 (serine threonine kinase)
  • serine/threonine protein kinase PIM-2
  • EC.number 2.7.1.37/ 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 5.95 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - DXS1061 ,DXS1214 - DXS997 - DXS1058 ,DXS993 - DXS1201 ,DXS8026 - PIM2 - GATA1 - DXS1039 - qter
    Authors GeneMap (98)
    Physical map
    SLC38A5 Xp11.23 solute carrier family 38, member 5 FTSJ1 Xp11.23 FtsJ homolog 1 (E. coli) PPN Xp11.23 likely ortholog of mouse porcupine homolog (Drosophila) EBP Xp11.23-p11.22 emopamil binding protein (sterol isomerase) OATL1 Xp11.23-p11.22 ornithine aminotransferase-like 1 RBM3 Xp11.23 RNA binding motif protein 3 MRPL32P1 Xq11.23 RNA binding motif protein 3 WDR13 Xp11.23 WD repeat domain 13 WAS Xp11.23-p11.22 Wiskott-Aldrich syndrome (eczema-thrombocytopenia) SUV39H1 Xp11.23 suppressor of variegation 3-9 homolog 1 (Drosophila) LOC392465 X similar to RIKEN cDNA 2010001H14 LOC389854 X similar to Acetyl-coenzyme A acyltransferase 2 GATA1 Xp11.23 GATA binding protein 1 (globin transcription factor 1) HDAC6 Xp11.23 histone deacetylase 6 ERAS Xpter-q26 ES cell expressed Ras PCSK1N Xp11.23 proprotein convertase subtilisin/kexin type 1 inhibitor TIMM17B Xp11.23 translocase of inner mitochondrial membrane 17 homolog B (yeast) PQBP1 Xp11.3 polyglutamine binding protein 1 SLC35A2 Xp11.23-p11.22 solute carrier family 35 (UDP-galactose transporter), member A2 PIM2 Xp11.3-p11.2 pim-2 oncogene DKFZp761A052 Xp11.23 hypothetical protein DKFZp761A052 KCND1 Xp11.23 potassium voltage-gated channel, Shal-related subfamily, member 1 GRIPAP1 Xp11 GRIP1 associated protein 1 TFE3 Xp11.23-p11.22 transcription factor binding to IGHM enhancer 3 JM11 Xp11.23 JM11 protein JM4 Xp11.23 JM11 protein JM5 Xp11.23 JM5 protein T54 Xp11.23 T54 protein FLJ21687 Xp11.23 PDZ domain containing, X chromosome PLP2 Xp11.23 proteolipid protein 2 (colonic epithelium-enriched) LMO6 Xp11.23-p11.22 LIM domain only 6 SYP Xp11.23-p11.22 synaptophysin CACNA1F Xp11.23 calcium channel, voltage-dependent, alpha 1F subunit LOC347348 Xp11.23 similar to Heat shock 27 kDa protein (HSP 27) (Stress-responsive protein 27) (SRP27) (Estrogen-regulated 24 kDa protein) (28 kDa heat shock protein) JM1 Xp11.23 JM1 protein FOXP3 Xp11.23 forkhead box P3 PPP1R3F Xp11.23 protein phosphatase 1, regulatory (inhibitor) subunit 3F LOC286408 Xp11.23 hypothetical LOC286408 LOC389855 X similar to G antigen 7
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2234 34 311 - 2012 22506047
  • short
  • has differential nuclear and cytoplasmic forms in all tested cell lines, suggesting a possible role for the balance between these forms for PIM2 function
  • - - 5000 41 - leukemia and lymphoma cell lines, testis (primary germ cells), small intestine, colon and colorectal adenocarcinoma cells 2012 22506047
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Digestiveintestinesmall intestine   
     intestinelarge intestinecolon  
    Endocrinepancreas    
    Reproductivemale systemtestis   
     male systemprostate   
    Respiratorylung    
    Skeletonappendicular skeleton     Homo sapiensAdult
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood/Hematopoieticbone marrow   
    Connectivecartilage    Homo sapiensAdult
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificchondrocyte Homo sapiensAdult
    Reproductivegerm cell
    cell lineage hematopoietic cell lineage
    cell lines leukemia and lymphoma cell lines,colorectal adenocarcinoma cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Pim-2 oncogene
    homolog to C.elegans prk-2
    Homologene
    FAMILY
  • SER/THR family of protein kinases
  • PIM family, related to camodulin-calcium family of protein-kinases
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • serine threonine kinase
  • having a role in proliferating cells as well as during meiosis
  • protected chondrocytes from rapamycin sensitized (TOR inhibited) cell death
  • regulates a new intermediate stage in the differentiation pathway, the induction of autophagy
  • PIM1 and PIM2 play a key role in the v-Abl transformation, possibly via participating in modulation of SOCS1 and via regulating the apoptotic signaling
  • promote cell cycle progression and tumorigenesis by down-regulating CDKN1B expression at both transcriptional and posttranslational levels
  • promotes liver tumorigenesis induction through mediating survival and preventing apoptosis of liver cell
  • involved in cell survival and cell proliferation
  • novel anti-apoptotic mediator in myeloma cells
  • can function as a potent survival factor, but it can, under certain circumstances, exhibit pro-apoptotic effects as well
  • PIM1, PIM2, PIM3 have been implicated in the regulation of apoptosis, metabolism, cell cycle, and homing and migration, which has led to the postulation of these proteins as interesting targets for anticancer drug discovery
  • CELLULAR PROCESS cell cycle,division,meiosis
    cell life, proliferation/growth
    cell life, antiapoptosis
    protein, post translation
    PHYSIOLOGICAL PROCESS
    text
  • control of cell proliferation
  • male meiosis
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
  • regulating the stability of SOCS1 protein
  • phosphorylating the pro-apoptotic protein BAD on serine 112, which accounts in part for its ability to reverse Bad-induced cell death
  • promoted expression and organization of autophagic proteins MAP1LC3A, and Beclin-1 and enhanced lysosomal acidification
  • phosphorylates the cell cycle inhibitor CDKN1A on Thr145
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in multiple B-cell lymphoma types, associated with an aggressive clinical course
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    PIM2 kinase inhibition is a rational approach in DLBCL treatment
    cancerhemopathy 
    new target for multiple myeloma treatment
    ANIMAL & CELL MODELS
    compound Pim knockhout mice show a profound reduction of body size and non efficient proliferation of peripheral T lymphocytes