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FLASH GENE
Symbol PIM2 contributors: mct - updated : 06-03-2015
HGNC name pim-2 oncogene
HGNC id 8987
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Pim-2 oncogene
homolog to C.elegans prk-2
Homologene
FAMILY
  • SER/THR family of protein kinases
  • PIM family, related to camodulin-calcium family of protein-kinases
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • serine threonine kinase
  • having a role in proliferating cells as well as during meiosis
  • protected chondrocytes from rapamycin sensitized (TOR inhibited) cell death
  • regulates a new intermediate stage in the differentiation pathway, the induction of autophagy
  • PIM1 and PIM2 play a key role in the v-Abl transformation, possibly via participating in modulation of SOCS1 and via regulating the apoptotic signaling
  • promote cell cycle progression and tumorigenesis by down-regulating CDKN1B expression at both transcriptional and posttranslational levels
  • PIM2 promotes liver tumorigenesis induction through mediating survival and preventing apoptosis of liver cell
  • involved in cell survival and cell proliferation
  • novel anti-apoptotic mediator in myeloma cells
  • can function as a potent survival factor, but it can, under certain circumstances, exhibit pro-apoptotic effects as well
  • PIM1, PIM2, PIM3 have been implicated in the regulation of apoptosis, metabolism, cell cycle, and homing and migration, which has led to the postulation of these proteins as interesting targets for anticancer drug discovery
  • CELLULAR PROCESS cell cycle,division,meiosis
    cell life, proliferation/growth
    cell life, antiapoptosis
    protein, post translation
    PHYSIOLOGICAL PROCESS
    text
  • control of cell proliferation
  • male meiosis
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
  • regulating the stability of SOCS1 protein
  • phosphorylating the pro-apoptotic protein BAD on serine 112, which accounts in part for its ability to reverse Bad-induced cell death
  • promoted expression and organization of autophagic proteins MAP1LC3A, and Beclin-1 and enhanced lysosomal acidification
  • phosphorylates the cell cycle inhibitor CDKN1A on Thr145
  • may inhibit the apoptosis of Prostate cancer cells (PCA) through phosphorylating EIF4B, thus promoting the tumorigenesis of PCA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in multiple B-cell lymphoma types, associated with an aggressive clinical course
    tumoral     --over  
    in Prostate cancer cell lines and tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    PIM2 kinase inhibition is a rational approach in DLBCL treatment
    cancerhemopathy 
    new target for multiple myeloma treatment
    ANIMAL & CELL MODELS
    compound Pim knockhout mice show a profound reduction of body size and non efficient proliferation of peripheral T lymphocytes