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FLASH GENE
Symbol PIK3C2A contributors: - updated : 03-05-2005
HGNC name phosphoinositide-3-kinase, class 2, alpha polypeptide
HGNC id 8971
Location 11p15.1      Physical location : 17.108.125 - 17.191.354
Synonym symbol(s) PI3K-C2alpha
EC.number 2.7.1.137
DNA
TYPE functioning gene
STRUCTURE 80.00 kb     32 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map see NUCB2
regionally located head to tail of RPS13
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   predominantly
Digestiveintestinelarge intestinecolon  
 pancreas exocrine    
Reproductivefemale systemplacenta   
 female systemuteruscervix  
Respiratoryrespiratory tractlarynx   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • lipid kinase catalytic domain
  • one px (phox homology) domain
  • a C terminal C2 domain
  • HOMOLOGY
    interspecies homolog to murine Pik3c2a
    Homologene
    FAMILY phosphoinositide 3-kinase (PI3K) family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • synthesis of phosphatidylinositide 3-phosphates
  • may be involved in integrin-dependent signaling
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    intracellular signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by insulin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS