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FLASH GENE

Symbol

PHB2

contributors: mct/npt/pgu - updated : 24-10-2017

HGNC name	prohibitin 2
HGNC id	30306

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12p13.31      Physical location : 7.074.516 - 7.079.916
Synonym name	repressor of estrogen receptor activity
	B-cell receptor-associated protein BAP37
	B-cell associated protein
Synonym symbol(s)	BAP, REA, p22, Bap37, BCAP37, PNAS-141

DNA

TYPE	functioning gene
STRUCTURE	5.40 kb     9 Exon(s)

regulatory sequence	Binding site
text structure	binding sites for the Myc oncoprotein

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001144831 10 - 1457 NP_001138303 - 299 - 2008 18086671 NM_007273 10 - 1416 NP_009204 - 299 - 2008 18086671

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   moderately   intestine small intestine     highly   pancreas exocrine       moderately   stomach       highly Lymphoid/Immune lymph node       highly Reproductive female system uterus cervix   highly   female system ovary     moderately Skin/Tegument skin       highly Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

PhosphoP

HOMOLOGY

interspecies	ortholog to rattus Bcap37
	ortholog to murine Bcap37

Homologene

FAMILY

prohibitin family

CATEGORY

regulatory , transcription factor , receptor nuclear

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,membrane
	intracellular,nucleus
text	present in various cellular compartments including the nucleus

basic FUNCTION	repressor of estrogen receptor activity
	negative regulation of transcription
	mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases
	playing a role in regulating mitochondrial respiratory activity and in aging
	phosphoprotein up-regulated during T cell activation that function to maintain mitochondrial integrity
	having diverse functions, such as the regulation of apoptosis and the maintenance of mitochondrial morphology
	membrane protein that is essential for cell proliferation and development in higher eukaryotes

CELLULAR PROCESS	cell life
	nucleotide, transcription, regulation
	cell organization/biogenesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

nucleic

signaling

DNA metabolism

a component

prohibitin-1 (PHB) and prohibitin-2 (PHB2), form large, multimeric ring complexes in the inner membrane of mitochondria

INTERACTION

DNA

RNA

small molecule

protein	PHB/PHB1
	HDAC1
	interacting with RNF2 and TFCP2 (RNF2 and PHB2 modulate the TFCP2-mediated transcriptional pathway)
	interacts with AKT1 and inhibits muscle differentiation by repressing the transcriptional activity of both MYOD1 and MEF2C
	CAMK4 specifically binds to the C terminus of PHB2 and phosphorylates PHB2 at serine 91
	PHB/PHB2 and the CD86 cytoplasmic domain cooperate to mediate CD86 signaling in a B cell through differential phosphorylation of distal signaling intermediates required to increase IGHG1
	SIGLEC9 bound to prohibitins PHB, PHB2, in a sialic acid-independent manner

cell & other

REGULATION

induced by

metabolic stress caused by an imbalance in the synthesis of mitochondrial- and nuclear-encoded mitochondrial proteins

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS