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FLASH GENE
Symbol PHB2 contributors: mct/npt/pgu - updated : 24-10-2017
HGNC name prohibitin 2
HGNC id 30306
Location 12p13.31      Physical location : 7.074.516 - 7.079.916
Synonym name
  • repressor of estrogen receptor activity
  • B-cell receptor-associated protein BAP37
  • B-cell associated protein
  • Synonym symbol(s) BAP, REA, p22, Bap37, BCAP37, PNAS-141
    DNA
    TYPE functioning gene
    STRUCTURE 5.40 kb     9 Exon(s)
    regulatory sequence Binding site
    text structure binding sites for the Myc oncoprotein
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1457 - 299 - 2008 18086671
    10 - 1416 - 299 - 2008 18086671
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon moderately
     intestinesmall intestine  highly
     pancreas exocrine   moderately
     stomach   highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemuteruscervix highly
     female systemovary  moderately
    Skin/Tegumentskin   highly
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to rattus Bcap37
    ortholog to murine Bcap37
    Homologene
    FAMILY
  • prohibitin family
  • CATEGORY regulatory , transcription factor , receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    text
  • present in various cellular compartments including the nucleus
  • basic FUNCTION
  • repressor of estrogen receptor activity
  • negative regulation of transcription
  • mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases
  • playing a role in regulating mitochondrial respiratory activity and in aging
  • phosphoprotein up-regulated during T cell activation that function to maintain mitochondrial integrity
  • having diverse functions, such as the regulation of apoptosis and the maintenance of mitochondrial morphology
  • membrane protein that is essential for cell proliferation and development in higher eukaryotes
  • CELLULAR PROCESS cell life
    nucleotide, transcription, regulation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    DNA metabolism
    a component
  • prohibitin-1 (PHB) and prohibitin-2 (PHB2), form large, multimeric ring complexes in the inner membrane of mitochondria
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PHB/PHB1
  • HDAC1
  • interacting with RNF2 and TFCP2 (RNF2 and PHB2 modulate the TFCP2-mediated transcriptional pathway)
  • interacts with AKT1 and inhibits muscle differentiation by repressing the transcriptional activity of both MYOD1 and MEF2C
  • CAMK4 specifically binds to the C terminus of PHB2 and phosphorylates PHB2 at serine 91
  • PHB/PHB2 and the CD86 cytoplasmic domain cooperate to mediate CD86 signaling in a B cell through differential phosphorylation of distal signaling intermediates required to increase IGHG1
  • cell & other
    REGULATION
    induced by metabolic stress caused by an imbalance in the synthesis of mitochondrial- and nuclear-encoded mitochondrial proteins
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS