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FLASH GENE
Symbol PHB2 contributors: mct/npt/pgu - updated : 24-10-2017
HGNC name prohibitin 2
HGNC id 30306
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
 intestinesmall intestine  highly
 pancreas exocrine   moderately
 stomach   highly
Lymphoid/Immunelymph node   highly
Reproductivefemale systemuteruscervix highly
 female systemovary  moderately
Skin/Tegumentskin   highly
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP
HOMOLOGY
interspecies ortholog to rattus Bcap37
ortholog to murine Bcap37
Homologene
FAMILY
  • prohibitin family
  • CATEGORY regulatory , transcription factor , receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    text
  • present in various cellular compartments including the nucleus
  • basic FUNCTION
  • repressor of estrogen receptor activity
  • negative regulation of transcription
  • mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases
  • playing a role in regulating mitochondrial respiratory activity and in aging
  • phosphoprotein up-regulated during T cell activation that function to maintain mitochondrial integrity
  • having diverse functions, such as the regulation of apoptosis and the maintenance of mitochondrial morphology
  • membrane protein that is essential for cell proliferation and development in higher eukaryotes
  • CELLULAR PROCESS cell life
    nucleotide, transcription, regulation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    DNA metabolism
    a component
  • prohibitin-1 (PHB) and prohibitin-2 (PHB2), form large, multimeric ring complexes in the inner membrane of mitochondria
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PHB/PHB1
  • HDAC1
  • interacting with RNF2 and TFCP2 (RNF2 and PHB2 modulate the TFCP2-mediated transcriptional pathway)
  • interacts with AKT1 and inhibits muscle differentiation by repressing the transcriptional activity of both MYOD1 and MEF2C
  • CAMK4 specifically binds to the C terminus of PHB2 and phosphorylates PHB2 at serine 91
  • PHB/PHB2 and the CD86 cytoplasmic domain cooperate to mediate CD86 signaling in a B cell through differential phosphorylation of distal signaling intermediates required to increase IGHG1
  • cell & other
    REGULATION
    induced by metabolic stress caused by an imbalance in the synthesis of mitochondrial- and nuclear-encoded mitochondrial proteins
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS