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FLASH GENE

Symbol

PGR

contributors: mct - updated : 22-06-2019

HGNC name	progesterone receptor
HGNC id	8910

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q22.1      Physical location : 100.900.354 - 101.000.544
Synonym symbol(s)	PROGR, PR, NR3C3

DNA

TYPE	functioning gene
STRUCTURE	100.19 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	resulting from two distinct transcripts,transcribed from distinct promoters of PRG gene

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed Progins - - - - - - 2007 17293450 a 320 bp PV/HS-1 Alu insertion in intron G and two point mutations, V660L in exon 4 and H770H (silent substitution) in exon 5 less responsive to progestin compared with the most common PGR because of reduced amounts of gene transcript and decreased protein activity PR-S - - - - - expressed in testis (spermatozoa) and lowly in endometrium 2002 11948021 a novel exon, exon S PR-T - - - - - - 2002 11948021 a previously unidentified 5'-sequence and the exons 4-8 (a novel exon T) NM_000926 8 - 13037 99 933 highly in uterine endometrium 2002 11948021 PR-B specific degradation of PR-B by UBE3A is critical for normal mammary gland development NM_001202474 - - 12287 - 769 - 2002 11948021 PR-A lacks 164 amino acids that are present at the N-terminus of PR-B

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system uterus     highly   female system breast mammary gland       female system ovary ovarian follicle     Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective         Epithelial barrier/lining endometrium

cells

System Cell Pubmed Species Stage Rna symbol Reproductive granulosa cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	zinc finger protein, class II
	a modulating N terminal domain
	DNA binding domain
	a hinge region regulating the kinetics of transcriptional responses through acetylation, phosphorylation, and nuclear retention
	C terminal steroid-binding domain

HOMOLOGY

interspecies

homolog to murine Pgr

Homologene

FAMILY

steroid/thyroid hormone receptor superfamily

CATEGORY

transcription factor , signaling hormone , receptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm

basic FUNCTION	progesterone receptor
	PR-A acting as a transcriptional repressor
	PR-B as an activator required for normal mammary development in the puberty
	involved in regulation of TRPV4 expression by progesterone
	nuclear receptor transcription factor that is essential for female fertility, in part due to its control of oocyte release from the ovary, or ovulation
	mediates the effects of progesterone by association with a range of coregulatory proteins and binding to specific target sequences in progesterone-regulated gene promoters
	in ovarian granulosa cells, PGR may act as an inducible coregulator for constitutively bound Sp1/Sp3 transcription factors, which are key regulators for a discrete cohort of ovulatory genes

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development , reproduction/sex

text

puberty

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	NCOA2 interacts with ESR1, ESR2 and PGR in a subtype-specific manner, which may contribute to the functional differences of these steroid receptor subtypes in brain
	coregulator function of MAGEA11 extends to isoform-specific regulation of PGR during the cyclic development of the human endometrium
	TNFSF11 is a direct PGR target gene and STAT5A has a novel role as a cofactor in PGR-mediated transcriptional signaling in the mammary gland
	ARID1A positively regulates KLF15 expression with PGR to inhibit epithelial proliferation at peri-implantation
	WBP2 acts as a transcriptional coactivator for ESR1 and progesterone receptor (PGR)
	ovarian cycle-related Progesterone and neurosteroids regulate GABRA2 expression in the hippocampus via a non-PGR pathway, which may be relevant to menstrual-cycle related brain conditions
	ZFHX3 is an integral transcription factor of PGR signaling in driving side-branching and alveologenesis during mammary gland development

cell & other

REGULATION

Other	regulated by UBE3A (UBE3A controls mammary gland development by regulating PR-B protein turnover via the ubiquitin proteasome pathway)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in meningioma with good prognosis

Susceptibility

to idiopathic recurrent pregnancy loss

Variant & Polymorphism other	PROGINS polymorphism confers susceptibility to idiopathic recurrent pregnancy loss

Candidate gene	may be a candidate for association with preterm birth or familial preterm birth
Marker
Therapy target

ANIMAL & CELL MODELS