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FLASH GENE
Symbol PGR contributors: mct - updated : 22-06-2016
HGNC name progesterone receptor
HGNC id 8910
Location 11q22.1      Physical location : 100.900.354 - 101.000.544
Synonym symbol(s) PROGR, PR, NR3C3
DNA
TYPE functioning gene
STRUCTURE 100.19 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
text resulting from two distinct transcripts,transcribed from distinct promoters of PRG gene
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - - - - - 2007 17293450
  • a 320 bp PV/HS-1 Alu insertion in intron G and two point mutations, V660L in exon 4 and H770H (silent substitution) in exon 5
  • less responsive to progestin compared with the most common PGR because of reduced amounts of gene transcript and decreased protein activity
  • - - - - - expressed in testis (spermatozoa) and lowly in endometrium 2002 11948021
    a novel exon, exon S
    - - - - - - 2002 11948021
    a previously unidentified 5'-sequence and the exons 4-8 (a novel exon T)
    8 - 13037 99 933 highly in uterine endometrium 2002 11948021
  • PR-B
  • specific degradation of PR-B by UBE3A is critical for normal mammary gland development
  • - - 12287 - 769 - 2002 11948021
  • PR-A
  • lacks 164 amino acids that are present at the N-terminus of PR-B
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuterus  highly
     female systembreastmammary gland  
     female systemovaryovarian follicle   Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    Epithelialbarrier/liningendometrium  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegranulosa cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • zinc finger protein, class II
  • a modulating N terminal domain
  • DNA binding domain
  • a hinge region regulating the kinetics of transcriptional responses through acetylation, phosphorylation, and nuclear retention
  • C terminal steroid-binding domain
  • HOMOLOGY
    interspecies homolog to murine Pgr
    Homologene
    FAMILY steroid/thyroid hormone receptor superfamily
    CATEGORY transcription factor , signaling hormone , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • progesterone receptor
  • PR-A acting as a transcriptional repressor
  • PR-B as an activator required for normal mammary development in the puberty
  • involved in regulation of TRPV4 expression by progesterone
  • nuclear receptor transcription factor that is essential for female fertility, in part due to its control of oocyte release from the ovary, or ovulation
  • mediates the effects of progesterone by association with a range of coregulatory proteins and binding to specific target sequences in progesterone-regulated gene promoters
  • in ovarian granulosa cells, PGR may act as an inducible coregulator for constitutively bound Sp1/Sp3 transcription factors, which are key regulators for a discrete cohort of ovulatory genes
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development , reproduction/sex
    text puberty
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NCOA2 interacts with ESR1, ESR2 and PGR in a subtype-specific manner, which may contribute to the functional differences of these steroid receptor subtypes in brain
  • coregulator function of MAGEA11 extends to isoform-specific regulation of PGR during the cyclic development of the human endometrium
  • TNFSF11 is a direct PGR target gene and STAT5A has a novel role as a cofactor in PGR-mediated transcriptional signaling in the mammary gland
  • ARID1A positively regulates KLF15 expression with PGR to inhibit epithelial proliferation at peri-implantation
  • ovarian cycle-related Progesterone and neurosteroids regulate GABRA2 expression in the hippocampus via a non-PGR pathway, which may be relevant to menstrual-cycle related brain conditions
  • cell & other
    REGULATION
    Other regulated by UBE3A (UBE3A controls mammary gland development by regulating PR-B protein turnover via the ubiquitin proteasome pathway)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in meningioma with good prognosis
    Susceptibility to idiopathic recurrent pregnancy loss
    Variant & Polymorphism other
  • PROGINS polymorphism confers susceptibility to idiopathic recurrent pregnancy loss
  • Candidate gene
  • may be a candidate for association with preterm birth or familial preterm birth
  • Marker
    Therapy target
    ANIMAL & CELL MODELS