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FLASH GENE
Symbol PGR contributors: mct - updated : 22-06-2019
HGNC name progesterone receptor
HGNC id 8910
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • zinc finger protein, class II
  • a modulating N terminal domain
  • DNA binding domain
  • a hinge region regulating the kinetics of transcriptional responses through acetylation, phosphorylation, and nuclear retention
  • C terminal steroid-binding domain
    • HOMOLOGY
    interspecies homolog to murine Pgr
    Homologene
    FAMILY steroid/thyroid hormone receptor superfamily
    CATEGORY transcription factor , signaling hormone , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • progesterone receptor
  • PR-A acting as a transcriptional repressor
  • PR-B as an activator required for normal mammary development in the puberty
  • involved in regulation of TRPV4 expression by progesterone
  • nuclear receptor transcription factor that is essential for female fertility, in part due to its control of oocyte release from the ovary, or ovulation
  • mediates the effects of progesterone by association with a range of coregulatory proteins and binding to specific target sequences in progesterone-regulated gene promoters
  • in ovarian granulosa cells, PGR may act as an inducible coregulator for constitutively bound Sp1/Sp3 transcription factors, which are key regulators for a discrete cohort of ovulatory genes
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development , reproduction/sex
    text puberty
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NCOA2 interacts with ESR1, ESR2 and PGR in a subtype-specific manner, which may contribute to the functional differences of these steroid receptor subtypes in brain
  • coregulator function of MAGEA11 extends to isoform-specific regulation of PGR during the cyclic development of the human endometrium
  • TNFSF11 is a direct PGR target gene and STAT5A has a novel role as a cofactor in PGR-mediated transcriptional signaling in the mammary gland
  • ARID1A positively regulates KLF15 expression with PGR to inhibit epithelial proliferation at peri-implantation
  • WBP2 acts as a transcriptional coactivator for ESR1 and progesterone receptor (PGR)
  • ovarian cycle-related Progesterone and neurosteroids regulate GABRA2 expression in the hippocampus via a non-PGR pathway, which may be relevant to menstrual-cycle related brain conditions
  • ZFHX3 is an integral transcription factor of PGR signaling in driving side-branching and alveologenesis during mammary gland development
    • cell & other
    REGULATION
    Other regulated by UBE3A (UBE3A controls mammary gland development by regulating PR-B protein turnover via the ubiquitin proteasome pathway)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in meningioma with good prognosis
    Susceptibility to idiopathic recurrent pregnancy loss
    Variant & Polymorphism other
  • PROGINS polymorphism confers susceptibility to idiopathic recurrent pregnancy loss
    • Candidate gene
  • may be a candidate for association with preterm birth or familial preterm birth
    • Marker
    Therapy target
    ANIMAL & CELL MODELS