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FLASH GENE
Symbol PFKFB1 contributors: mct - updated : 19-04-2008
HGNC name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
HGNC id 8872
Location Xp11.21      Physical location : 54.959.589 - 55.020.511
Synonym name
  • 6PF-2-K/Fru-2,6-P2ASE liver isozyme
  • fructose-2,6-bisphosphatase
  • Synonym symbol(s) PFRX, F6PK, HL2K, MGC116715, MGC116717
    EC.number 2.7.1.105, 3.1.3.46
    DNA
    TYPE functioning gene
    STRUCTURE 60.00 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map pter - PFKFB1 - ALAS2 - cen
    Authors Batra (97)
    Physical map
    KIAA0522 Xp11.23 KIAA0522 protein SMC1L1 Xp11.22-p11.21 SMC1 structural maintenance of chromosomes 1-like 1 (yeast) FLJ32783 Xp11.23 hypothetical protein FLJ32783 HADH2 Xp11.2 hydroxyacyl-Coenzyme A dehydrogenase, type II UREB1 Xp11.23-p11.21 hydroxyacyl-Coenzyme A dehydrogenase, type II LOC389859 X similar to 28S ribosomal protein S18c, mitochondrial precursor (MRP-S18-c) (Mrps18c) (MRP-S18-1) (CGI-134) KIAA1111 Xp11.22 Homo sapiens KIAA1111 protein (KIAA1111), mRNA. FLJ20506 Xp11.22 hypothetical protein FLJ20506 PRKWNK3 Xp11.23-p11.21 protein kinase, lysine deficient 3 DT1P1A10 Xp11.22 hypothetical protein DT1P1A10 FGD1 Xp11.21 faciogenital dysplasia (Aarskog-Scott syndrome) FLJ10613 Xp11.22 hypothetical protein FLJ10613 LOC392473 X similar to dJ834A16.1 (similar to PGAM) UNQ6369 Xp11.22 ITI-like protein MAGED2 Xp11.2 melanoma antigen, family D, 2 TRO Xp11.22-p11.21 trophinin PFKFB1 Xp11.21 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 APEX2 Xp11.22 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 ALAS2 Xp11.21 aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia) LOC389860 X similar to PAGE-5 protein LOC203569 Xp11.22 similar to PAGE-5 protein LOC90736 Xp11.22 hypothetical protein BC000919 PAGE-5 Xp11.22 PAGE-5 protein LOC139793 Xp11.22 similar to XAGE-5 protein MAGEH1 Xp11.22 APR-1 protein LOC158880 LOC392474 X similar to hypothetical protein MGC21658 Xp11.22 similar to Forkhead box protein N4 LOC392475 X similar to XAGE-5 protein RRAGB Xp11.21 Ras-related GTP binding B LOC392476 X similar to Got2-prov protein KLF8 Xp11.21 Kruppel-like factor 8 UBQLN2 Xp11.23-p11.1 ubiquilin 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 1733 - 471 - Ross(2005)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Lymphoid/Immunethymus    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Pfkb1
    Homologene
    FAMILY phosphoglycerase mutase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in fructose 2,6-P2 synthesis and degradation
  • activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS