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FLASH GENE
Symbol PEG3 contributors: mct/pgu - updated : 18-03-2010
HGNC name paternally expressed 3
HGNC id 8826
Location 19q13.43      Physical location : 57.321.444 - 57.352.094
Synonym name
  • putative imprinted ZNF
  • zinc finger and SCAN domain-containing protein 24
  • human homolog of a mouse imprinted gene, Peg3
  • Kruppel-type zinc finger protein
  • maternally imprinted
  • Synonym symbol(s) KIAA0287, PW1, ZSCAN24, DKFZp781A095
    DNA
    TYPE anonymous DNA segment
    SPECIAL FEATURE
    text sharing identical 5' and composed of seven small exons with ZIM2
    STRUCTURE 28.27 kb     10 Exon(s)
    regulatory sequence cytosine-phosphate-guanine/HTF
    text structure the region surrounding the first exon of PEG3 contains a differentially methylated CpG island
    MAPPING cloned Y linked N status provisional
    Map cen - PRKCG - ZIM2 - PEG3 - (ZNF134 - ZNF132 - MZF1 ),USP29 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 8375 - 1462 - 2002 11679586
  • using an alternate in-frame downstream start codon as compared to variant 1
  • isoform 2
  • - - 8689 - 1588 - 2002 11679586
  • missing a 5' non coding exon as compared to variant 1
  • isoform 1
  • 10 - 8765 - 1588 - 2002 11679586
  • isoform 1
  • - - 8722 - 1588 - 2002 11679586
  • differs in the 5'UTR as compared to variant 1
  • isoform 1
  • - - 8381 - 1464 - 2002 11679586
  • using an alternate in-frame downstream start codon as compared to variant 1
  • isoform 3 with a shorter N terminus and two additional internal aa as compared to isoform 1
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrineadrenal gland   highly
     neuroendocrinepituitary  highly
     placenta    
    Nervousbraindiencephalonhypothalamus  
    Reproductivefemale systemovary  predominantly
     male systemtestis  predominantly
    Respiratorylung   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousastrocyte
    Nervousglia
    cell lineage
    cell lines highly repressed in glioma cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text placenta, mesodermal tissues (branchial arches, somites)
    IMPRINTING maternally
    text in placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 12 C2H2-type zinc fingers
  • two novel proline-rich motifs
  • leucine-rich repeats
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • Krüppel C2H2-type zinc finger protein family
  • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • contributing to glioma carcinogenesis
  • involved in the TP53-mediated cell death pathway as a downstream effector of TP53 in brain ischemia/hypoxia
  • inhibits Wnt signaling and regulates glioma growth
  • inducing apoptosis in ccoperation with SIAH1A
  • acting as a mediator between TP53 and BAX in a neuronal death pathway that is activated by DNA damage
  • acting synergistically with TRAF2 and inhibits TNF-induced apoptosis through activation of NF-KappaB
  • possesses a tumor suppressor activity in glioma cells
  • serves as an invaluable marker for competent self-renewing stem cells in a wide array of adult tissues
  • PEG3/reporter activity identifies stem/progenitor cells of the adult CNS and can be used to track a self-renewing population
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SIAH1A and SIAH2
  • interacting with TRAF2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in glioma (by aberrant DNA methylation of an exonic CpG island)
    Susceptibility for cancer as well as neurobehavioral deficits
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS