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FLASH GENE
Symbol PEG3 contributors: mct/pgu - updated : 18-03-2010
HGNC name paternally expressed 3
HGNC id 8826
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrineadrenal gland   highly
 neuroendocrinepituitary  highly
 placenta    
Nervousbraindiencephalonhypothalamus  
Reproductivefemale systemovary  predominantly
 male systemtestis  predominantly
Respiratorylung   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousastrocyte
Nervousglia
cell lineage
cell lines highly repressed in glioma cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text placenta, mesodermal tissues (branchial arches, somites)
IMPRINTING maternally
text in placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 12 C2H2-type zinc fingers
  • two novel proline-rich motifs
  • leucine-rich repeats
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • Krüppel C2H2-type zinc finger protein family
  • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • contributing to glioma carcinogenesis
  • involved in the TP53-mediated cell death pathway as a downstream effector of TP53 in brain ischemia/hypoxia
  • inhibits Wnt signaling and regulates glioma growth
  • inducing apoptosis in ccoperation with SIAH1A
  • acting as a mediator between TP53 and BAX in a neuronal death pathway that is activated by DNA damage
  • acting synergistically with TRAF2 and inhibits TNF-induced apoptosis through activation of NF-KappaB
  • possesses a tumor suppressor activity in glioma cells
  • serves as an invaluable marker for competent self-renewing stem cells in a wide array of adult tissues
  • PEG3/reporter activity identifies stem/progenitor cells of the adult CNS and can be used to track a self-renewing population
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SIAH1A and SIAH2
  • interacting with TRAF2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in glioma (by aberrant DNA methylation of an exonic CpG island)
    Susceptibility for cancer as well as neurobehavioral deficits
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS