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FLASH GENE
Symbol PEA15 contributors: mct/npt/shn - updated : 25/12/2010
HGNC name phosphoprotein enriched in astrocytes 15
HGNC id 8822
Location 1q23.3      Physical location : 160.175.124 - 160.185.160
Synonym name
  • phosphoprotein enriched in astrocytes, 15kD
  • homolog of mouse MAT-1 oncogene
  • 15 kDa phosphoprotein enriched in astrocytes
  • astrocytic phosphoprotein PEA-15
  • phosphoprotein enriched in diabetes
    • Synonym symbol(s) PED, HMAT1, MAT1, MAT1H, PEA-15, HUMMAT1H, RP11-536C5.8
    DNA
    TYPE functioning gene
    STRUCTURE 10.04 kb     4 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D1S1167 - D1S2707 - PEA15 - D1S2771 - D1S484 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2474 15 130 a major phosphoprotein in astrocytes - 7861130
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately Homo sapiens
    Endocrineadrenal gland   moderately Homo sapiens
    Lymphoid/Immunespleen   lowly Homo sapiens
     thymus   highly Homo sapiens
    Respiratorylung   moderately Homo sapiens
    Urinarykidney   moderately Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousastrocyte Homo sapiens
    cell lineage
    cell lines some breast cancer lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a death effector domain (DED)
    • HOMOLOGY
    interspecies ortholog to Pea15a, Mus musculus
    ortholog to Pea15a, Rattus norvegicus
    Homologene
    FAMILY
    CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • may contribute to insulin resistance in glucose uptake in type 2 diabetes
  • involved in its regulation of integrin activation
  • death effector domain-containing protein, which is involved in the regulation of apoptotic cell death
  • involved in astrocytic protection against deleterious effects of TNF
  • can redirect the biological outcome of MAP kinase signaling by regulating the subcellular localization of ERK MAP kinase
  • controlling glucose uptake
  • protects glioblastoma cells from glucose deprivation-induced apoptosis via the ERK/MAP kinase pathway
  • functions as a scaffold to enhance ERK activation of RSK2, and this activity is regulated by phosphorylation
  • promotes autophagy in glioma cells in a JNK-dependent manner
  • in addition to apoptosis, is involved in the regulation of other major cellular functions, including cell adhesion, migration, proliferation and glucose metabolism
  • blocks ERK-dependent gene transcription and inhibits proliferation by sequestering ERK in the cytoplasm (
  • not only suppresses ERK signaling and tumorigenesis but also alternatively enhances tumorigenesis in the context of active HRAS
    • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Fas (TNFRSF6)-associated via death domain, FADD and FADD-like ICE, FLICE
  • phospholipase D1, PLD1 and phospholipase D2, PLD2
  • blocks ERK MAP kinase
  • ribosomal S6 kinase 2, RSK2
  • Protein kinase B/Akt
  • HtrA serine peptidase 2, HTRA2
  • phospholipase D1, PLD1
  • PEA15 phosphorylation by PLCG1 is required for PDGFA-induced ERK1/2 nuclear translocation
  • molecular interaction of PEA15 with RPSA (PEA15 ability to induce cell responses to ECM-derived signals through interaction with RPSA may be of crucial importance for tumour cell survival in a poor microenvironment, thus favouring the metastatic spread and colonization)
  • positively regulates HRAS/ERK signaling and increases the proliferation of HRas-transformed epithelial cells through enhanced PLD1 expression and activation
    • cell & other
    REGULATION
    Phosphorylated by PDGFA and this phosphorylation required activation of PLCG1
    Other phosphorylated in astrocytes by CaMKII and by protein kinase C in response to endothelin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in some breast cancer lines
    constitutional     --over  
    induces a marked resistance against glucose deprivation-induced apoptosis
    constitutional     --over  
    overexpression represents a common defect in first-degre relatives of patients with type 2 diabetes and is correlated with reduced insulin sensitivity
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • PEA-15 expression increases astrocyte survival after exposure to TNF in PEA-15 null mutant mice