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FLASH GENE

Symbol

PDPN

contributors: mct - updated : 08-06-2011

HGNC name	podoplanin
HGNC id	29602

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p36.21      Physical location : 13.910.251 - 13.944.450
Synonym name	lung type-I cell membrane-associated glycoprotein
	Aggrus/T1alpha
Synonym symbol(s)	GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2

DNA

TYPE	functioning gene
STRUCTURE	34.00 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed Variant 1 - splicing 2828 24.8 238 - Martin-Villar Variant 3 - splicing 2652 12.3 120 - Martin-Villar Variant 2 - splicing 2822 24.5 236 - Martin-Villar Variant 4 - splicing 2646 12 118 - Martin-Villar

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue     highly Lymphoid/Immune lymphatic vessel       highly Homo sapiens Nervous plexus choroid       highly Reproductive female system uterus       Urinary kidney nephron renal capsule glomerulus highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Homo sapiens Skin/Tegument keratinocyte Urinary podocyte

cell lineage
cell lines	expressed in seminoma, squamous cell carcinoma, malignant mesothelioma, sarcomas and several brain tumors
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

PLAG domains, critical for platelet aggregation-inducing activity

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

CATEGORY

antigen , receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
text	type-I integral membrane

basic FUNCTION	mucine-type glycoprotein, may be a differentiation antigen and influenza-virus receptor
	may be a marker of lung injury
	platelet aggregation-inducing factor expressed in colorectal tumors
	specific marker of lymphatic endothelium
	role for LGALS8 and PDPN in supporting the connection of the lymphatic endothelium to the surrounding extracellular matrix, most likely in cooperation with other glycoproteins on the surface of lymphatic endothelial cells
	promotes directional persistence of motility in epithelial cells, a feature that requires CD44, and both molecules cooperate to promote directional migration in squamous stratified epithelia (SCCs) cells
	is required to protect the barrier function of high endothelial venules (HEVs) during lymphocyte trafficking

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with CD44 (role for CD44-podoplanin interaction in driving tumor cell migration during malignancy)
	activation of CLEC1B by PDPN rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces
	CLEC1B is a natural ligand/receptor for PDPN, in the formation of the lymphatic vasculature
	local sphingosine-1-phosphate release after PDPN–CLEC1B-mediated platelet activation is critical for high endothelial venules (HEVs) integrity during immune responses

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation     loss of function leads to abnormal lung development tumoral     --over   in squamous cell carcinomas, germ cell tumors and colorectal cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mice with postnatal deletion of Pdpn lost high endothelial venules (HEVs) integrity and exhibited spontaneous bleeding in mucosal lymph nodes, and bleeding in the draining peripheral lymph nodes after immunization