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FLASH GENE
Symbol PDPN contributors: mct - updated : 08-06-2011
HGNC name podoplanin
HGNC id 29602
DNA
TYPE functioning gene
STRUCTURE 34.00 kb     8 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2828 24.8 238 - Martin-Villar
- splicing 2652 12.3 120 - Martin-Villar
- splicing 2822 24.5 236 - Martin-Villar
- splicing 2646 12 118 - Martin-Villar
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Lymphoid/Immunelymphatic vessel   highly Homo sapiens
Nervousplexus choroid   highly
Reproductivefemale systemuterus   
Urinarykidneynephronrenal capsuleglomerulushighly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell Homo sapiens
Skin/Tegumentkeratinocyte
Urinarypodocyte
cell lineage
cell lines expressed in seminoma, squamous cell carcinoma, malignant mesothelioma, sarcomas and several brain tumors
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
PLAG domains, critical for platelet aggregation-inducing activity
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY
CATEGORY antigen , receptor membrane
SUBCELLULAR LOCALIZATION     plasma membrane
text type-I integral membrane
basic FUNCTION
  • mucine-type glycoprotein, may be a differentiation antigen and influenza-virus receptor
  • may be a marker of lung injury
  • platelet aggregation-inducing factor expressed in colorectal tumors
  • specific marker of lymphatic endothelium
  • role for LGALS8 and PDPN in supporting the connection of the lymphatic endothelium to the surrounding extracellular matrix, most likely in cooperation with other glycoproteins on the surface of lymphatic endothelial cells
  • promotes directional persistence of motility in epithelial cells, a feature that requires CD44, and both molecules cooperate to promote directional migration in squamous stratified epithelia (SCCs) cells
  • is required to protect the barrier function of high endothelial venules (HEVs) during lymphocyte trafficking
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CD44 (role for CD44-podoplanin interaction in driving tumor cell migration during malignancy)
  • activation of CLEC1B by PDPN rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces
  • CLEC1B is a natural ligand/receptor for PDPN, in the formation of the lymphatic vasculature
  • local sphingosine-1-phosphate release after PDPN–CLEC1B-mediated platelet activation is critical for high endothelial venules (HEVs) integrity during immune responses
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation     loss of function
    leads to abnormal lung development
    tumoral     --over  
    in squamous cell carcinomas, germ cell tumors and colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice with postnatal deletion of Pdpn lost high endothelial venules (HEVs) integrity and exhibited spontaneous bleeding in mucosal lymph nodes, and bleeding in the draining peripheral lymph nodes after immunization