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FLASH GENE
Symbol PDGFA contributors: mct - updated : 19-12-2017
HGNC name platelet-derived growth factor alpha polypeptide
HGNC id 8799
Location 7p22.3      Physical location : 536.898 - 559.481
Synonym name
  • PDGF A-chain
  • platelet-derived growth factor alpha chain
  • platelet-derived growth factor alpha isoform 2 preproprotein
  • Synonym symbol(s) PDGF1, PDGF-A, PDGF
    DNA
    TYPE functioning gene
    STRUCTURE 23.42 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    CENTA1 7q31.1-q31.33 centaurin, alpha 1 MGC20460 7q36.3 hypothetical protein MGC20460 LOC392965 7 similar to alpha-2-glycoprotein 1, zinc; Alpha-2-glycoprotein, zinc FLJ14117 LOC392614 7 similar to MUC-B1 LOC392734 7 similar to Williams-Beuren syndrome critical region protein 19 PMS2L9 7q11.23 postmeiotic segregation increased 2-like 9 FLJ20359 7p22.3 hypothetical protein FLJ20359 HIP1 7q11.23 huntingtin interacting protein 1 COL26A1 7q22.1 collagen, type XXVI, alpha 1 MGC11257 7p22.3 hypothetical protein MGC11257 SHH 7q36 sonic hedgehog homolog (Drosophila) GPR146 7p22.3 G protein-coupled receptor 146 LOC392854 7 similar to spasmolysin precursor - African clawed frog GPR30 7p22 G protein-coupled receptor 30 FLJ20397 7p22.3 hypothetical protein FLJ20397 LOC90637 7p22.3 hypothetical protein LOC90637 UNC84A 7p22.3 unc-84 homolog A (C. elegans) LOC340260 7p22.3 similar to Unc4.1 homeobox PDGFA 7p22 platelet-derived growth factor alpha polypeptide LOC392848 7 hypothetical gene supported by AK124321 CCL26 7q11.23 chemokine (C-C motif) ligand 26 MYLC2PL 7q22.1 myosin light chain 2, precursor lymphocyte-specific C7orf20 7p22.3 chromosome 7 open reading frame 20 CCL24 7q11.23 chemokine (C-C motif) ligand 24 CENTA1 7q31.1-q31.33 centaurin, alpha 1 LOC392939 7 similar to ALY
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2809 24.04 211 - 2014 24703957
    encoding for the longer isoform 1
    6 splicing 2740 22.2 196 - 2014 24703957
    encoding for the shorter isoform 2
    EXPRESSION
    Rna function mRNA was expressed in granulosa cells of a minority of the samples from women/girls
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveesophagus   highly
     mouth   lowly
    Nervousnerve   highly
    Reproductivefemale systemovary  moderately
    Visualeye   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoietic   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet
    Reproductivegranulosa cell Homo sapiens
    Reproductiveoocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion secreted
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 20 amino acids signal peptide (2.1 kDa)
  • a 191 amino acids proprotein (21.9 kDa)
  • an 8 cysteine residues
  • a C terminal basic motif
  • mono polymer homomer , heteromer , dimer
    isoforms Precursor a 125 amino acids mature peptide (14.3 kDa)
    HOMOLOGY
    interspecies homolog to rattus Pdgfa (91.19 pc)
    homolog to murine Pdgfa (92.23 pc)
    Homologene
    FAMILY
  • PDGF/VEGF growth factor family
  • CATEGORY signaling cytokine growth factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • potent mitogen for cells of mesenchymal origin, also involved in transformation process
  • regulating the development of the craniofacial structures
  • induces neovascularization by priming vascular smooth muscle cells /pericytes to release pro-angiogenic mediators (Greenberg 2008)
  • regulates salivary gland morphogenesis via fibroblast growth factor expression (Yamamoto 2008)
  • mesodermal PDGF signaling is not essential in heart development, although its role may be redundant with other signaling pathways (Kang 2008)
  • might be involved in the activation of primordial follicles
  • regulates the interaction of MTSS1L with either wild type or constitutively activated MYC-RAC1 proteins
  • PDGFA signalling might regulate EZH2 expression and age-dependent pancreatic beta-cell proliferation in islets
  • thought to function as a key player in the development and progression of tumor growth by regulating aspects of cell proliferation, angiogenesis and metastasis
  • regulates chondrocyte proliferation through activation of ERK1/2 pathway by upregulation of GIT1 expression and RAC1 phosphorylation
  • PDGFA and TGFB1 regulate acute respiratory distress syndrome (ARDS)-associated lung fibrosis through distinct signaling pathway-mediated activation of fibrosis-related proteins
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    cell-cell signaling
    a component
  • homodimerizing or heterodimerizing with PDGFB
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDGFRA, PDGFRB
  • CSPG4
  • interacting with KDR and VEGFA
  • PLCG1 is involved with PDGFA in phosphorylation of PEA15
  • by mediating intensive F-actin accumulation at the sites of cell infiltration, WASF2, WASL, and ENAH are crucial for PI3K-dependent cell invasion induced by PDGFA
  • association of MUC1 with PDGFA and MUC1 regulates the expression and secretion of PDGFA
  • activates the proximal 980-bp region of the IL13 promoter
  • RDX, EZR, MSN exert a redundant control on PDGFA-induced vascular smooth muscle cells (VSMC) migration by regulating focal adhesion turn-over and cell adhesion to substrate
  • SOX11 promotes tumor angiogenesis through transcriptional regulation of PDGFA in mantle cell lymphoma
  • SRF regulates craniofacial development through selective recruitment of MKL1 cofactors by PDGFA signaling
  • PDGFA-induced migration of mesenchymal cells requires NOX4 and DUOX1/2 enzymes, which mediate redox-sensitive activation of PI3-kinase pathway and PKB/AKT1
  • PI3CA/AKT2 is a direct PDGFA target that is activated in f adipocyte stem cells (ASCs) during white adipose tissue (WAT) hyperplasia and is functionally required for dermal ASC proliferation
  • PDGFA/PDGFRA signalling as a tissue-autonomous regulator of contact inhibition of locomotion (CIL) by controlling N-cadherin upregulation during epithelial-to-mesenchymal transition (EMT)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    expression of PDGFA and its receptor increased in patients with more serious age-related cataracts
    tumoral       gain of function
    is frequently upregulated in various cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurosensorialvisuallens
    may be a new therapeutic target for cataracts treatment
    respiratorylung 
    treatments with both PDGFA and TGFB1 antagonists may result in a better anti-fibrotic outcome for acute lung injury (ALI)-induced lung fibrosis
    ANIMAL & CELL MODELS