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FLASH GENE
Symbol PDE4B contributors: mct/npt/pgu - updated : 06-02-2018
HGNC name phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
HGNC id 8781
Location 1p31.3      Physical location : 66.258.192 - 66.840.261
Synonym name
  • dunce-like phosphodiesterase E4
  • phosphodiesterase 4B, cAMP-specific
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B
  • Synonym symbol(s) DPDE4, MGC126529, PDEIVB, DKFZp686F2182, PDE32, PDE4B5
    EC.number 3.1.4.17/ 3.1.4.53
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 582.07 kb     17 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    motif Viral sequence   long terminal repeat
    text structure specific HERV-K LTR 50 kb downstream
    MAPPING cloned Y linked N status confirmed
    Map pter - D1S2886 - D1S2866 - PDE4B - D1S198 - D1S3166 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 4264 - 736 - 2003 12441002
  • Va, or PDE4B1 or Tm72
  • interacts with the DISC1 protein, implicated in neural development and behavioral disorders
  • 10 - 3884 - 564 - 2003 12441002
  • Vb or PDE4B2 or PDE32
  • is an effector of Toll-like receptor signaling in astrocytes
  • 15 - 4364 - 721 - 2003 12441002
  • Vc or PDE4B3
  • 17 - 4309 - 736 - 2003 12441002
  • PDE4B1 or Tm72
  • 16 - 4070 - 644 - 2003 12441002
    17 - 3963
    10 - 3888 - 503 - 2003 12441002
  • PDE4B5
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain    
    Respiratorylung     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticneutrophil Homo sapiens
    not specificfibroblast Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to Drosophila dunce gene
    Homologene
    FAMILY
  • cyclic nucleotide phosphodiesterase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text abundant in synaptosomes
    basic FUNCTION
  • may be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents
  • is an effector of Toll-like receptor signaling in astrocytes, and its up-regulation at the protein level is controlled by complex mechanisms
  • predominant role of PDE4B in controlling pathophysiological processes of human lung fibroblasts
  • PDE4B mediates a crucial PKA-dependent feedback that controls ADRB1-dependent cAMP signals in a restricted subsarcolemmal domain
  • may be involved in the testicular abnormalities of men with Down syndrome and cryptorchidism
  • does not play an important role during the chemotactic response of human neutrophils
  • plays a critical role in coordinating alcohol-induced, peripheral endotoxemia mediated neuro-inflammation
  • probable role of PDE4B1 in synaptic plasticity and behavior
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • DISC1-PDE4B complexes are therefore likely to be involved in molecular mechanisms underlying psychiatric illness
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with DISC1 (DISC1/PDE4B interaction is likely to be of particular importance in psychiatric illness)
  • DISC1 acts as an assembly scaffold for NDE1/NDEL1/PDE4B and the NDE1/NDEL1/LIS1/dynein complex is modulated by cAMP levels via PRKCA and PDE4B
  • upregulation of NOX4 leads to an upregulation of PDE4A, PDE4B, and PDE4D and increased hydrolysis of cAMP which in turn augments cell replication and angiogenesis
  • expression of ZNF804A results in a statistically significant decrease in transcript levels of PDE4B and DRD2
  • negatively regulates CYLD via specific activation of MAPK9, but not MAPK8
  • is an important phosphodiesterase in the hippocampal formation, is a major Disrupted in Schizophrenia 1 (DISC1) binding partner and is itself a risk gene for psychiatric illness
  • AMPK antagonizes hepatic glucagon signalling via phosphorylation-induced PDE4B activation
  • cell & other
    REGULATION
    inhibited by rolipram
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
        translocation    
    disrupted by a balanced translocation in a subject diagnosed with schizophrenia and a relative with chronic psychiatric illness
    tumoral     --over  
    in CD4+ lymphoid cancer cells, which suggests that it may represent a physiological role unique to the CD8+ and lymphoid cancer cells
    tumoral     --low  
    in advanced prostate cancer
    constitutional     --low  
    may be involved in the neurological abnormalities in subjects with Down syndrome
    Susceptibility to schizophrenia (through binding with DISC1)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetemetabolic syndrom 
    potential utility of PDE4B-selective inhibitors for the treatment of cognitive impairment and obesity-related metabolic diseases
    obesity  
    potential utility of PDE4B-selective inhibitors for the treatment of cognitive impairment and obesity-related metabolic diseases
    neurologyneurodegenerative 
    potential utility of PDE4B-selective inhibitors for the treatment of cognitive impairment and obesity-related metabolic diseases
    ANIMAL & CELL MODELS