protein
| interacting with DISC1 (DISC1/PDE4B interaction is likely to be of particular importance in psychiatric illness) |
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DISC1 acts as an assembly scaffold for NDE1/NDEL1/PDE4B and the NDE1/NDEL1/LIS1/dynein complex is modulated by cAMP levels via PRKCA and PDE4B |
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upregulation of NOX4 leads to an upregulation of PDE4A, PDE4B, and PDE4D and increased hydrolysis of cAMP which in turn augments cell replication and angiogenesis |
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expression of ZNF804A results in a statistically significant decrease in transcript levels of PDE4B and DRD2 |
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negatively regulates CYLD via specific activation of MAPK9, but not MAPK8 |
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is an important phosphodiesterase in the hippocampal formation, is a major Disrupted in Schizophrenia 1 (DISC1) binding partner and is itself a risk gene for psychiatric illness |
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AMPK antagonizes hepatic glucagon signalling via phosphorylation-induced PDE4B activation |