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FLASH GENE
Symbol PDE4B contributors: mct/npt/pgu - updated : 06-02-2018
HGNC name phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
HGNC id 8781
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to Drosophila dunce gene
Homologene
FAMILY
  • cyclic nucleotide phosphodiesterase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text abundant in synaptosomes
    basic FUNCTION
  • may be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents
  • is an effector of Toll-like receptor signaling in astrocytes, and its up-regulation at the protein level is controlled by complex mechanisms
  • predominant role of PDE4B in controlling pathophysiological processes of human lung fibroblasts
  • PDE4B mediates a crucial PKA-dependent feedback that controls ADRB1-dependent cAMP signals in a restricted subsarcolemmal domain
  • may be involved in the testicular abnormalities of men with Down syndrome and cryptorchidism
  • does not play an important role during the chemotactic response of human neutrophils
  • plays a critical role in coordinating alcohol-induced, peripheral endotoxemia mediated neuro-inflammation
  • probable role of PDE4B1 in synaptic plasticity and behavior
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • DISC1-PDE4B complexes are therefore likely to be involved in molecular mechanisms underlying psychiatric illness
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with DISC1 (DISC1/PDE4B interaction is likely to be of particular importance in psychiatric illness)
  • DISC1 acts as an assembly scaffold for NDE1/NDEL1/PDE4B and the NDE1/NDEL1/LIS1/dynein complex is modulated by cAMP levels via PRKCA and PDE4B
  • upregulation of NOX4 leads to an upregulation of PDE4A, PDE4B, and PDE4D and increased hydrolysis of cAMP which in turn augments cell replication and angiogenesis
  • expression of ZNF804A results in a statistically significant decrease in transcript levels of PDE4B and DRD2
  • negatively regulates CYLD via specific activation of MAPK9, but not MAPK8
  • is an important phosphodiesterase in the hippocampal formation, is a major Disrupted in Schizophrenia 1 (DISC1) binding partner and is itself a risk gene for psychiatric illness
  • AMPK antagonizes hepatic glucagon signalling via phosphorylation-induced PDE4B activation
  • cell & other
    REGULATION
    inhibited by rolipram
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
        translocation    
    disrupted by a balanced translocation in a subject diagnosed with schizophrenia and a relative with chronic psychiatric illness
    tumoral     --over  
    in CD4+ lymphoid cancer cells, which suggests that it may represent a physiological role unique to the CD8+ and lymphoid cancer cells
    tumoral     --low  
    in advanced prostate cancer
    constitutional     --low  
    may be involved in the neurological abnormalities in subjects with Down syndrome
    Susceptibility to schizophrenia (through binding with DISC1)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetemetabolic syndrom 
    potential utility of PDE4B-selective inhibitors for the treatment of cognitive impairment and obesity-related metabolic diseases
    obesity  
    potential utility of PDE4B-selective inhibitors for the treatment of cognitive impairment and obesity-related metabolic diseases
    neurologyneurodegenerative 
    potential utility of PDE4B-selective inhibitors for the treatment of cognitive impairment and obesity-related metabolic diseases
    ANIMAL & CELL MODELS