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FLASH GENE

Symbol

PCSK4

contributors: - updated : 14-01-2006

HGNC name	proprotein convertase subtilisin/kexin type 4
HGNC id	8746

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.3      Physical location : 1.481.426 - 1.490.407
Synonym name	paired basic amino-acid residue cleaving enzyme 4
Synonym symbol(s)	PC4, SPC5

DNA

TYPE	functioning gene
STRUCTURE	2.00 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage	only, in testicular germ cells
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a preprodomain
	a subtilisin-like catalytic, serine protease domain Ca2+ dependent
	conserved homo b/p domain
	a furin cysteine-rich region
	a transmembrane anchor
	a cytoplasmic domain

isoforms

Precursor

autocatalytically activated

HOMOLOGY

Homologene

FAMILY

proprotein convertase subtilisin kexin-like (SPC) subtilase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	paired basic amino acid residue cleaving enzyme
	represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the rx(k/r)r consensus motif

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	calcium

protein

cell & other

REGULATION

inhibited by

the not secondly cleaved propeptide

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS