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FLASH GENE
Symbol PCSK4 contributors: - updated : 14-01-2006
HGNC name proprotein convertase subtilisin/kexin type 4
HGNC id 8746
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a preprodomain
  • a subtilisin-like catalytic, serine protease domain Ca2+ dependent
  • conserved homo b/p domain
  • a furin cysteine-rich region
  • a transmembrane anchor
  • a cytoplasmic domain
    • isoforms Precursor autocatalytically activated
    HOMOLOGY
    Homologene
    FAMILY proprotein convertase subtilisin kexin-like (SPC) subtilase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • paired basic amino acid residue cleaving enzyme
  • represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the rx(k/r)r consensus motif
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium
    protein
    cell & other
    REGULATION
    inhibited by the not secondly cleaved propeptide
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS