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FLASH GENE
Symbol PCDH7 contributors: mct - updated : 19-07-2008
HGNC name protocadherin 7
HGNC id 8659
Location 4p15.1      Physical location : 30.722.036 - 31.148.423
Synonym name
  • BH protocadherin
  • brain heart protocadherin
  • BH-protocadherin (brain-heart)
  • Synonym symbol(s) BHPCDH, BH-PCDH
    DNA
    TYPE functioning gene
    STRUCTURE 424.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LGI2 4p15.31 leucine-rich repeat LGI family, member 2 SLA/LP 4p15.31 soluble liver antigen/liver pancreas antigen PI4K2B 4p15.31 phosphatidylinositol 4-kinase type-II beta ANAPC4 4p15.31 anaphase-promoting complex subunit 4 LOC345348 4p15.31 similar to D-myo-inositol-3-phosphate synthase LOC391641 4 similar to chloroquine resistance marker protein SLC34A2 4p15.3-p15.1 solute carrier family 34 (sodium phosphate), member 2 KIAA0746 4p15.2 solute carrier family 34 (sodium phosphate), member 2 LOC389203 4 hypothetical gene supported by BC032431 RBPSUH 9p13-p12 recombining binding protein suppressor of hairless (Drosophila) CCKAR 4p15.2-p15.1 cholecystokinin A receptor FLJ11082 4p15.31 hypothetical protein FLJ11082 STIM2 4p15.2 stromal interaction molecule 2 LOC389204 4 LOC389204 MRPL51P1 4p15.2 LOC389204 LOC391642 4 similar to Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (B cell signal transduction molecule alpha 4) (Alpha 4 protein) LOC285509 4p15.2 hypothetical LOC285509 LOC391643 4 similar to mesoderm specific transcript isoform a; paternally expressed gene 1 PCDH7 4p15.1 BH-protocadherin (brain-heart) LOC391644 4 similar to Microtubule-associated protein RP/EB family member 1 LOC133185 4p15.1 similar to 9530003A05 protein CENTD1 4p14 centaurin, delta 1 MGC42157 4p15.1 hypothetical protein MGC42157
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 splicing 4646 116 1069 - Yoshida, Olsen (2006)
    - splicing 4900 116 1072 - Yoshida, Olsen (2006)
    4 splicing 8561 130 1200 - Yoshida, Olsen (2006)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Hearing/Equilibriumear   highly
    Nervousbrain   predominantly
     nerve   highly
    Urinarykidney   highly
    cell lineage
    cell lines in cancer cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • seven extracellular cadherin repeats
  • a transmembrane domain encoded by a large unique exon
  • a distinct cytoplasmic tail specifically interacting with tyrosine kinases
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Pcdh7 protocadherin
    intraspecies homolog to cadherin
    Homologene
    FAMILY
  • cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
  • protocadherin subfamily
  • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text integral plasma membrane localized at the synaptic junction
    basic FUNCTION
  • cadherin-related neuronal receptor, putatively involved in the specificity of neuronal connections
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development , nervous system
    text
  • playing a putative role in cell-cell interactions critical in the development of the central nervous system, mediating adhesion in synaptic junctions through lack-in process
  • PATHWAY
    metabolism
    signaling signal transduction
    cell-cell signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
  • cells expressing in the same protocadherin
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS