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FLASH GENE
Symbol PARVG contributors: - updated : 19-03-2005
HGNC name parvin, gamma
HGNC id 14654
Location 22q13.2-q13      Physical location : 44.568.835 - 44.603.034
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
text located about 12 kb downstream of the 3' end of PARVB
STRUCTURE 23.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
TTLL1 22q13.1 tubulin tyrosine ligase-like 1 BIK 22q13.31 BCL2-interacting killer (apoptosis-inducing) MT 22q13.31 malonyl-CoA:acyl carrier protein transacylase (malonyltransferase) BZRP 22q13.31 benzodiazapine receptor (peripheral) KIAA0153 22q13.31 benzodiazapine receptor (peripheral) SCUBE1 22q13.2-q13.3 signal peptide, CUB domain, EGF-like 1 DKFZp547I094 22q13.31 hypothetical protein DKFZp547I094 LOC388908 22 similar to chromosome 22 open reading frame 1; adult brain protein 239 FLJ23588 22q13.1-q13.33 CAP-binding protein complex interacting protein 1 YWHAQP2 22q12-qter YWHAQ pseudogene 2 HMG17L1 22q13.31 high-mobility group (nonhistone chromosomal) protein 17-like 1 SULT4A1 22q13.2-q13.31 sulfotransferase family 4A, member 1 LOC150379 22q13.31 GS2 like C22orf20 22q13.31 chromosome 22 open reading frame 20 CGI-51 22q13.31 CGI-51 protein PARVB 22q13.2-q13.33 parvin, beta TRSPP1 22q11 tRNA phosphoserine (opal suppressor) pseudogene 1 PARVG 22q13.2-q13 parvin, gamma LOC388909 22 LOC388909 MRPS18CP6 22q13.31 mitochondrial ribosomal protein S18C pseudogene 6 DKFZp761O17121 22q13.31 hypothetical protein DKFZp761O17121 LOC129186 22q13.31 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC388910 22 LOC388910 ARHGAP8 22q13.31 Rho GTPase activating protein 8 LOC112885 22q13.31 hypothetical protein BC012187 NUP50 22q13.31 nucleoporin 50kDa KIAA0930 22q13.31 nucleoporin 50kDa UPK3A 22q13.31 uroplakin 3A FLJ20635 22q13 hypothetical protein FLJ20635 SMC1L2 22q13.31 SMC1 structural maintenance of chromosomes 1-like 2 (yeast) DKFZP566F0546 22q13.31 DKFZP566F0546 protein
regionally located located about 12 kb downstream of the 3'end of PARVB
RNA
TRANSCRIPTS type messenger
text alternatively spliced and alternatively polyadenylated transcripts (korenbaum)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 1500 37.5 331 - Olski
- splicing 1000 - 187 - Goward unpublished
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text downregulated in embryonic tissue
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two calponin-homology (CM) domains
HOMOLOGY
interspecies ortholog to murine Parvg
ortholog to Drosophila Cg12533
ortholog to C.elegans Pat-6
intraspecies paralog to PARVA
paralog to PARVB
Homologene
FAMILY parvin family of focal adhesion proteins
CATEGORY adhesion
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
text located to focal adhesions
basic FUNCTION
  • playing a role in the regulation of cell adhesion and cytoskeleton organsation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding to ILK and actin
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS