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FLASH GENE

Symbol

PARVG

contributors: - updated : 19-03-2005

HGNC name	parvin, gamma
HGNC id	14654

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	22q13.2-q13      Physical location : 44.568.835 - 44.603.034

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
text	located about 12 kb downstream of the 3' end of PARVB
STRUCTURE	23.00 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

located about 12 kb downstream of the 3'end of PARVB

RNA

TRANSCRIPTS	type	messenger

text	alternatively spliced and alternatively polyadenylated transcripts (korenbaum)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - splicing 1500 37.5 331 - Olski variant 2 - splicing 1000 - 187 - Goward unpublished

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	downregulated in embryonic tissue

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two calponin-homology (CM) domains

HOMOLOGY

interspecies	ortholog to murine Parvg
	ortholog to Drosophila Cg12533
	ortholog to C.elegans Pat-6

intraspecies	paralog to PARVA
	paralog to PARVB

Homologene

FAMILY

parvin family of focal adhesion proteins

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
text	located to focal adhesions

basic FUNCTION

playing a role in the regulation of cell adhesion and cytoskeleton organsation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binding to ILK and actin

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS