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FLASH GENE
Symbol PARVG contributors: - updated : 19-03-2005
HGNC name parvin, gamma
HGNC id 14654
Location 22q13.2-q13      Physical location : 44.568.835 - 44.603.034
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
text located about 12 kb downstream of the 3' end of PARVB
STRUCTURE 23.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
regionally located located about 12 kb downstream of the 3'end of PARVB
RNA
TRANSCRIPTS type messenger
text alternatively spliced and alternatively polyadenylated transcripts (korenbaum)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 1500 37.5 331 - Olski
- splicing 1000 - 187 - Goward unpublished
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text downregulated in embryonic tissue
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two calponin-homology (CM) domains
HOMOLOGY
interspecies ortholog to murine Parvg
ortholog to Drosophila Cg12533
ortholog to C.elegans Pat-6
intraspecies paralog to PARVA
paralog to PARVB
Homologene
FAMILY parvin family of focal adhesion proteins
CATEGORY adhesion
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
text located to focal adhesions
basic FUNCTION
  • playing a role in the regulation of cell adhesion and cytoskeleton organsation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding to ILK and actin
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS