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FLASH GENE
Symbol PANX3 contributors: mct/ - updated : 06-03-2010
HGNC name pannexin 3
HGNC id 20573
Location 11q24.2      Physical location : 124.481.452 - 124.490.249
Synonym name gap junction protein pannexin 3
Synonym symbol(s) PX3
DNA
TYPE functioning gene
STRUCTURE 8.80 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
OR8G1 11q24.2 olfactory receptor, family 8, subfamily G, member 1 LOC219865 11q24.2 similar to seven transmembrane helix receptor LOC283159 11q24.2 similar to Olfactory receptor 8D1 (Olfactory receptor-like protein JCG9) (OST004) LOC283160 11q24.2 similar to Olfactory receptor 8D2 (Olfactory receptor-like protein JCG2) OR8B7P 11q25 olfactory receptor, family 8, subfamily B, member 7 pseudogene OR8B6P 11q25 olfactory receptor, family 8, subfamily B, member 6 pseudogene OR8B5P 11q25 olfactory receptor, family 8, subfamily B, member 5 pseudogene OR8B1P 11q24-q25 olfactory receptor, family 8, subfamily B, member 1 pseudogene OR8C1P 11q24-q25 olfactory receptor, family 8, subfamily C, member 1 pseudogene LOC390271 11 similar to seven transmembrane helix receptor LOC390272 11 similar to seven transmembrane helix receptor LOC283162 11q24.2 similar to Olfactory receptor 8B4 OR8B8 11q24.2 olfactory receptor, family 8, subfamily B, member 8 LOC390273 11 similar to Olfactory receptor 8A1 (OST025) OR8B9P 11q25 olfactory receptor, family 8, subfamily B, member 9 pseudogene LOC390274 11 similar to olfactory receptor MOR161-5 LOC219858 11q24.2 similar to Olfactory receptor 8B12 LOC390275 11 similar to Olfactory receptor 8A1 (OST025) PANX3 11q24.2 pannexin 3 TBRG1 11q24.2 likely ortholog of mouse transforming growth factor beta regulated gene 1 CSE-C 11q24 cytosolic sialic acid 9-O-acetylesterase homolog SPA17 11q24.2 sperm autoantigenic protein 17 NRGN 11q24 neurogranin (protein kinase C substrate, RC3) CTXL 11q24 cortical thymocyte receptor (X. laevis CTX) like ESAM 11q24.2 cortical thymocyte receptor (X. laevis CTX) like FLJ23342 11q24.2 hypothetical protein FLJ23342 RBIG1 11q24.2 retinoblastoma inhibiting gene 1 ROBO4 11q24.2 roundabout homolog 4, magic roundabout (Drosophila) FLJ25530 11q24.2 hypothetical protein FLJ25530
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1609 - 392 - 2007 17925379
EXPRESSION
Rna function
  • mRNA was expressed in the prehypertrophic zone in the developing growth plate
  • Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinnercochlea highly Homo sapiens
    Skin/Tegumentskin     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivecartilage    Homo sapiens
    Muscularstriatumskeletal   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificchondrocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • pannexin family
  • gap junction family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • with PANX1 have many characteristics that are distinct from GJA1 and these proteins probably play an important biological role as single membrane channels
  • play a role in gap junctional intercellular communication and as single-membrane channels, although many of its molecular characteristics differ from connexins (important role for pannexin glycosylation in trafficking)
  • like connexins, may play an important role in hearing
  • may have functions to switch the chondrocyte cell fate from proliferation to differentiation by regulating the intracellular ATP/cAMP levels
  • regulator of the switching mechanism behind the transition of chondrocytes from a proliferative state to a postmitotic state and that it is required for chondrocyte differentiation
  • functioned as a unique Ca(2+) channel in the endoplasmic reticulum (ER), which was activated by (PI3K)/Akt signaling, followed by activation of calmodulin signaling for differentiation
  • regulator that promotes osteoblast differentiation by functioning as an ER Ca(2+) channel and a hemichannel, and by forming gap junctions
  • PANX1 and PANX3 are co-expressed in human skeletal muscle myoblasts and play a pivotal role in dictating the proliferation and differentiation status of these cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • structural component of the GAP junction
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can interact with PANX1 and to a lesser extent, with PANX2 in a glycosylation-dependent manner
  • may serve an important role in bone development, and is a novel target for RUNX2-dependent signaling
  • cell & other
    REGULATION
    Other regulated by glycosylation (regulates pannexin intermixing and cellular localization)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS