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FLASH GENE
Symbol PANX3 contributors: mct/ - updated : 06-03-2010
HGNC name pannexin 3
HGNC id 20573
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY
  • pannexin family
  • gap junction family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • with PANX1 have many characteristics that are distinct from GJA1 and these proteins probably play an important biological role as single membrane channels
  • play a role in gap junctional intercellular communication and as single-membrane channels, although many of its molecular characteristics differ from connexins (important role for pannexin glycosylation in trafficking)
  • like connexins, may play an important role in hearing
  • may have functions to switch the chondrocyte cell fate from proliferation to differentiation by regulating the intracellular ATP/cAMP levels
  • regulator of the switching mechanism behind the transition of chondrocytes from a proliferative state to a postmitotic state and that it is required for chondrocyte differentiation
  • functioned as a unique Ca(2+) channel in the endoplasmic reticulum (ER), which was activated by (PI3K)/Akt signaling, followed by activation of calmodulin signaling for differentiation
  • regulator that promotes osteoblast differentiation by functioning as an ER Ca(2+) channel and a hemichannel, and by forming gap junctions
  • PANX1 and PANX3 are co-expressed in human skeletal muscle myoblasts and play a pivotal role in dictating the proliferation and differentiation status of these cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • structural component of the GAP junction
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can interact with PANX1 and to a lesser extent, with PANX2 in a glycosylation-dependent manner
  • may serve an important role in bone development, and is a novel target for RUNX2-dependent signaling
  • cell & other
    REGULATION
    Other regulated by glycosylation (regulates pannexin intermixing and cellular localization)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS