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FLASH GENE

Symbol

PAGE4

contributors: mct/npt - updated : 12-09-2018

HGNC name	P antigen family, member 4 (prostate associated)
HGNC id	4108

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	Xp11.23      Physical location : 49.593.905 - 49.598.570
Synonym name	G antigen, family C, 1
	prostate associated gene 4
Synonym symbol(s)	GAGEC1, PAGE-4, PAGE1, GAGE9, JM27, FLJ35184

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	5.05 kb     5 Exon(s)

regulatory sequence

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_007003 5 - 790 NP_008934 - 102 - 2014 24559171 NM_001318877 5 - 778 NP_001305806 - 102 - 2014 24559171

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system oviduct         female system uterus         female system placenta         female system ovary         male system testis         male system prostate     highly Homo sapiens Fetal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

intraspecies

homolog to a family of MAGE/GAGE-like proteins

Homologene

FAMILY

GAGE (G antigen) family

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
text	in cells under stress, translocation of PAGE4 to mitochondria increases while production of reactive oxygen species decreases

basic FUNCTION	multi-functional cytokine that plays a fundamental role during embryonic development
	is the first example of a cancer/testis antigens (CTA) that is an intrinsically disordered protein (IDP) with an anti-apoptotic function
	in cells under stress, translocation of PAGE4 to mitochondria increases while production of reactive oxygen species decreases
	PAGE4 may be contributing to the development of PCa by playing a stress-protective and anti-apoptotic role
	appears to act both as an oncogenic factor as well as a metastasis suppressor

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	JUN is a PAGE4 interacting partner(involved in the phosphorylation of PAGE4, and PAGE4 robustly potentiates JUN transactivation
	induces conformational changes in natively disordered PAGE4 resulting in its decreased affinity for JUN to promote interaction of JUN with another, unidentified, partner
	HIPK1-phosphorylated PAGE4 (HIPK1-PAGE4) potentiates JUN, whereas CLK2-phosphorylated PAGE4 (CLK2-PAGE4) attenuates JUN activity
	conformational switching of PAGE4 may potentially affect the efficiency of therapeutically targeting AR activity
	hyperphosphorylation of PAGE4 by CLK2 attenuates this interaction with AP1

cell & other

REGULATION

Phosphorylated by

HIPK1, a component of the stress-response pathway

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in prostate, testicular and uterine cancers tumoral     --over   in benign prostatic hyperplasia

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	is a prognostic target in prostate carcinoma
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate disrupting PAGE4/JUN interactions using small molecules may represent a novel therapeutic strategy for Prostate carcinoma cancer reproductive prostate represents a promising target for therapeutic intervention of benign prostatic hyperplasia and prostate cancer

ANIMAL & CELL MODELS