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FLASH GENE
Symbol PAGE4 contributors: mct/npt - updated : 12-09-2018
HGNC name P antigen family, member 4 (prostate associated)
HGNC id 4108
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 5.05 kb     5 Exon(s)
regulatory sequence
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 790 - 102 - 2014 24559171
5 - 778 - 102 - 2014 24559171
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemoviduct   
 female systemuterus   
 female systemplacenta   
 female systemovary   
 male systemtestis   
 male systemprostate  highly Homo sapiensFetal
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to a family of MAGE/GAGE-like proteins
Homologene
FAMILY
  • GAGE (G antigen) family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text
  • in cells under stress, translocation of PAGE4 to mitochondria increases while production of reactive oxygen species decreases
  • basic FUNCTION
  • multi-functional cytokine that plays a fundamental role during embryonic development
  • is the first example of a cancer/testis antigens (CTA) that is an intrinsically disordered protein (IDP) with an anti-apoptotic function
  • in cells under stress, translocation of PAGE4 to mitochondria increases while production of reactive oxygen species decreases
  • PAGE4 may be contributing to the development of PCa by playing a stress-protective and anti-apoptotic role
  • appears to act both as an oncogenic factor as well as a metastasis suppressor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • JUN is a PAGE4 interacting partner(involved in the phosphorylation of PAGE4, and PAGE4 robustly potentiates JUN transactivation
  • induces conformational changes in natively disordered PAGE4 resulting in its decreased affinity for JUN to promote interaction of JUN with another, unidentified, partner
  • HIPK1-phosphorylated PAGE4 (HIPK1-PAGE4) potentiates JUN, whereas CLK2-phosphorylated PAGE4 (CLK2-PAGE4) attenuates JUN activity
  • conformational switching of PAGE4 may potentially affect the efficiency of therapeutically targeting AR activity
  • hyperphosphorylation of PAGE4 by CLK2 attenuates this interaction with AP1
  • cell & other
    REGULATION
    Phosphorylated by HIPK1, a component of the stress-response pathway
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate, testicular and uterine cancers
    tumoral     --over  
    in benign prostatic hyperplasia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a prognostic target in prostate carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    disrupting PAGE4/JUN interactions using small molecules may represent a novel therapeutic strategy for Prostate carcinoma
    cancerreproductiveprostate
    represents a promising target for therapeutic intervention of benign prostatic hyperplasia and prostate cancer
    ANIMAL & CELL MODELS