| basic FUNCTION
| progestagen-associated endometrial protein, secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first trimester of pregnancy |
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demonstrating potential immunosuppresive properties |
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having immunomodulatory activity, implicated in the protection of the fetus from the maternal immune attack (inhibit the proliferation of T and B-cells and the activity of NK cells) |
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progesterone regulated lipocalin |
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may act as an autocrine factor within endometriotic implants to increase VEGF expression during oxidative stress |
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acts as a tumor suppressor in breast cancer  |
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contributes to the cytokine shift in early pregnancy |
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protective role during pregnancy by regulating the cytolytic activity of CD8(+) T cells |
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role of in supporting immune tolerance in pregnancy by reducing T cell effector functions along with augmenting Treg differentiation |
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lipocalin with an immunomodulatory role |
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inhibits activation and proliferation, and induces apoptosis of T cells |
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role as a paracrine regulator in early pregnancy |
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involved in fetomaternal defense and early placental development through its regulatory activities in various immune cells |
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cell surface glycoprotein offering a unique gender specific carbohydrate configuration (PMID; |
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is the principal secretory phase product of endometrium and has been shown to inhibit cell immune function |
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may play an important role in the pathogenesis of endometriosis |
