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FLASH GENE
Symbol P2RY2 contributors: mct/pgu - updated : 19-01-2013
HGNC name purinergic receptor P2Y, G-protein coupled, 2
HGNC id 8541
Location 11q13.4      Physical location : 72.929.343 - 72.947.393
Synonym name
  • purinoceptor P2Y2
  • P2U purinoceptor 1
  • ATP receptor
  • Synonym symbol(s) PZY2, P2U, HP2U, P2U1, P2UR, P2Y2, P2RU1, P2Y2R, MGC20088, MGC40010
    DNA
    TYPE functioning gene
    STRUCTURE 18.05 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC390222 11 hypothetical gene supported by U08471; Z32564; NM_000804 FOLR1 11q13.3-q13.5 folate receptor 1 (adult) FOLR2 11q13.3-q13.5 folate receptor 2 (fetal) INPPL1 11q23 inositol polyphosphate phosphatase-like 1 PHOX2A 11q13.3-q13.4 paired-like (aristaless) homeobox 2a LOC220077 11q13.3 hypothetical gene supported by AF229166 LOC390223 11 similar to Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 snRNP auxiliary factor small subunit) SKD3 11q13.3 suppressor of potassium transport defect 3 ART2P 11q13 ADP-ribosyltransferase 2 pseudogene (RT6 antigen homolog, rat) PDE2A 11cen-q12.1 phosphodiesterase 2A, cGMP-stimulated CENTD2 11q13.3 centaurin, delta 2 STARD10 11q13 START domain containing 10 FLJ00012 11q13.3 hypothetical protein FLJ00012 KIAA0769 11q13.2 hypothetical protein FLJ00012 P2RY2 11q13.5-q14.1 purinergic receptor P2Y, G-protein coupled, 2 P2RY6 11q13.5 pyrimidinergic receptor P2Y, G-protein coupled, 6 ARHGEF17 11q13.3-q13.5 Rho guanine nucleotide exchange factor (GEF) 17 TNFRSF19L 11q13,3 tumor necrosis factor receptor superfamily, member 19-like LOC387786 11 LOC387786 KIAA0280 11q13.3 KIAA0280 protein PLEKHB1 11q13.5-q14.1 pleckstrin homology domain containing, family B (evectins) member 1 RAB6A 2q14-q21 RAB6A, member RAS oncogene family LOC268276 11q13 musashi 1 pseudogene MRPL48 11q13.2 mitochondrial ribosomal protein L48 E2IG2 11q13.3 E2IG2 protein FLJ11848 11q13.3 hypothetical protein FLJ11848 TSARG6 11q13.3 testis spermatogenesis apoptosis-related protein 6 UCP2 11q13 uncoupling protein 2 (mitochondrial, proton carrier) UCP3 11q13 uncoupling protein 3 (mitochondrial, proton carrier) DKFZP586P0123 11q13.3 DKFZP586P0123 protein
    RNA
    TRANSCRIPTS type messenger
    text three variants encoding the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 splicing 2681 42 377 - 1997 9211988
    3 splicing 2547 42 377 - 1997 9211988
  • differring in the 5' UTR compared to variant 1
  • 3 splicing 2613 42 377 - 1997 9211988
  • differring in the 5' UTR compared to variant 1
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrineadrenal gland    
     pancreas     Homo sapiensmRNA
    Nervousbrain   moderately Homo sapiens
    Reproductivefemale systemovary   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines osteoblastic and brain cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • targeting signal between the N terminus and 7TM
  • seven transmembrane segments
  • one rhodopsin-like GPCR superfamily motif
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • may be involved in cell ion homeostasis
  • G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
  • playing a role as a morphogen receptor potentiating neurotrophin signaling in neuronal development and regeneration
  • may participate in control of the cell cycle of endometrial carcinoma cells
  • involved in signal amplification, controlling ATP gradient sensing and migration of neutrophils
  • involved in nucleotide-induced primary granule release from neutrophils, requiring fibrinogen
  • G-protein-coupled receptor activated by extracellular nucleotides, undergoes desensitization at many tissues, including the vascular endothelium
  • mediate Ca2+ signaling in duodenocytes and contribute to duodenal mucosal bicarbonate secretion
  • extracellular nucleotides, via P2RY2 and P2RY6, regulate neutrophil migration by controlling TLR2-induced IL8 release from human monocytes
  • mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ERBB3 in salivary gland cells
  • P2RY2 plays a major biological role in the corneal injury response and repair mechanisms
  • major purinergic receptor in human vascular endothelial cells that mediates the cellular actions of ATP linked to vasorelaxation
  • important roles of P2RY2 and ADRBK1 in chondrocyte mechanotransduction
  • mediates tissue factor expression in human coronary artery endothelial cells
  • P2RY2, and P2RY1 operate in tandem in inner medullary collecting duct cells to provide an adaptive mechanism for enhancing urinary NaCl excretion in the setting of high-dietary NaCl intake
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • P2RY2/FLNA interaction selectively regulates spreading and migration of vascular smooth muscle cells
  • plasma membrane distribution of P2RY2 is transregulated by EGFR, revealing an unsuspected functional interplay that controls both the membrane distribution and the vasomotor activity of the P2RY2 in intact human blood vessels
  • interacting with OTOP1
  • CEBPB is a novel regulator of P2RY2 expression
  • cell & other
    REGULATION
    Other predominantly responding to UTP
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    loss of P2RY2 immunoreactivity is associated with Alzheimer disease neuropathology
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS