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FLASH GENE
Symbol P2RY2 contributors: mct/pgu - updated : 19-01-2013
HGNC name purinergic receptor P2Y, G-protein coupled, 2
HGNC id 8541
RNA
TRANSCRIPTS type messenger
text three variants encoding the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 splicing 2681 42 377 - 1997 9211988
3 splicing 2547 42 377 - 1997 9211988
  • differring in the 5' UTR compared to variant 1
  • 3 splicing 2613 42 377 - 1997 9211988
  • differring in the 5' UTR compared to variant 1
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrineadrenal gland    
     pancreas     Homo sapiensmRNA
    Nervousbrain   moderately Homo sapiens
    Reproductivefemale systemovary   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines osteoblastic and brain cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • targeting signal between the N terminus and 7TM
  • seven transmembrane segments
  • one rhodopsin-like GPCR superfamily motif
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • may be involved in cell ion homeostasis
  • G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
  • playing a role as a morphogen receptor potentiating neurotrophin signaling in neuronal development and regeneration
  • may participate in control of the cell cycle of endometrial carcinoma cells
  • involved in signal amplification, controlling ATP gradient sensing and migration of neutrophils
  • involved in nucleotide-induced primary granule release from neutrophils, requiring fibrinogen
  • G-protein-coupled receptor activated by extracellular nucleotides, undergoes desensitization at many tissues, including the vascular endothelium
  • mediate Ca2+ signaling in duodenocytes and contribute to duodenal mucosal bicarbonate secretion
  • extracellular nucleotides, via P2RY2 and P2RY6, regulate neutrophil migration by controlling TLR2-induced IL8 release from human monocytes
  • mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ERBB3 in salivary gland cells
  • P2RY2 plays a major biological role in the corneal injury response and repair mechanisms
  • major purinergic receptor in human vascular endothelial cells that mediates the cellular actions of ATP linked to vasorelaxation
  • important roles of P2RY2 and ADRBK1 in chondrocyte mechanotransduction
  • mediates tissue factor expression in human coronary artery endothelial cells
  • P2RY2, and P2RY1 operate in tandem in inner medullary collecting duct cells to provide an adaptive mechanism for enhancing urinary NaCl excretion in the setting of high-dietary NaCl intake
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • P2RY2/FLNA interaction selectively regulates spreading and migration of vascular smooth muscle cells
  • plasma membrane distribution of P2RY2 is transregulated by EGFR, revealing an unsuspected functional interplay that controls both the membrane distribution and the vasomotor activity of the P2RY2 in intact human blood vessels
  • interacting with OTOP1
  • CEBPB is a novel regulator of P2RY2 expression
  • cell & other
    REGULATION
    Other predominantly responding to UTP
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    loss of P2RY2 immunoreactivity is associated with Alzheimer disease neuropathology
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS