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FLASH GENE

Symbol

OSBPL7

contributors: mct - updated : 09-02-2013

HGNC name	oxysterol binding protein-like 7
HGNC id	16387

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q21.32      Physical location : 45.884.732 - 45.899.147
Synonym name	OSBP-related protein 7
	oxysterol-binding protein-related protein 7
Synonym symbol(s)	ORP7, MGC71150

DNA

TYPE	functioning gene
STRUCTURE	14.41 kb     23 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_145798 23 - 3674 NP_665741 - 842 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine       highly Nervous brain diencephalon epithalamus pineal gland     brain basal nuclei

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal pleckstrin homology PH domain
	a highly conserved OSBP-type sterol binding domain in the C terminus

HOMOLOGY

Homologene

FAMILY

oxysterol binding protein family

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic

basic FUNCTION	may be involved in protein-protein and protein-lipid interactions
	putative role in communication between the ER and the plasma membrane

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interaction partner of OSBPL7, GABARAPL2 which regulates Golgi SNARE of 28kDa (GS28) function and stability, and plays a role in autophagosome biogenesis

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS