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FLASH GENE
Symbol OSBPL7 contributors: mct - updated : 09-02-2013
HGNC name oxysterol binding protein-like 7
HGNC id 16387
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   highly
Nervousbraindiencephalonepithalamuspineal gland 
 brainbasal nuclei   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal pleckstrin homology PH domain
  • a highly conserved OSBP-type sterol binding domain in the C terminus
  • HOMOLOGY
    Homologene
    FAMILY oxysterol binding protein family
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • may be involved in protein-protein and protein-lipid interactions
  • putative role in communication between the ER and the plasma membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction partner of OSBPL7, GABARAPL2 which regulates Golgi SNARE of 28kDa (GS28) function and stability, and plays a role in autophagosome biogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS