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FLASH GENE
Symbol ORMDL2 contributors: mct - updated : 27-08-2018
HGNC name ORM1-like 2 (S. cerevisiae)
HGNC id 16037
Location 12q13.2      Physical location : 56.211.805 - 56.214.959
Synonym name
  • ORM1 (S. cerevisiae)-like 2
  • expressed in normal aorta
  • adoplin-2
  • Synonym symbol(s) HSPC160, adoplin-2, MST095, MSTP095
    DNA
    TYPE functioning gene
    STRUCTURE 3.15 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1361 - 153 - 2012 23066021
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivefemale systembreastmammary gland  
     female systemplacenta   
    Respiratorylung    
    Urinarybladder    
     kidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period fetal
    Text heart, brain, lung, liver, kidney, spleen, thymus
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three putative transmembrane domains
  • HOMOLOGY
    interspecies homolog to rattus Ormdl2 (97.4pc)
    homolog to murine Ormdl2 (97.4pc)
    Homologene
    FAMILY
  • ORM family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • negative regulator of sphingolipid synthesis (Breslow 2010)
  • unique molecules with presenilin-related expression and functions that may play important role(s) in the maturation and activity of the gamma-secretase complex (Araki 2008)
  • Orm proteins are critical mediators of sphingolipid homeostasis, raising the possibility that sphingolipid misregulation contributes to the development of childhood asthma
  • ORMDL1, ORMDL2, ORMDL3 are the primary regulators of ceramide biosynthesis in mammalian cells, and constitute the major homeostatic regulators of ceramide biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SPTLC1 activity indirectly regulates ORMDL1, ORMDL2, ORMDL3 expression 2)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • may be a critical mediator of sphingolipid homeostasis and with sphingolipid dysregulation might contribute to the development of childhood asthma (Breslow 2010)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS