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FLASH GENE
Symbol ORMDL2 contributors: mct - updated : 27-08-2018
HGNC name ORM1-like 2 (S. cerevisiae)
HGNC id 16037
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three putative transmembrane domains
    • HOMOLOGY
    interspecies homolog to rattus Ormdl2 (97.4pc)
    homolog to murine Ormdl2 (97.4pc)
    Homologene
    FAMILY
  • ORM family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • negative regulator of sphingolipid synthesis (Breslow 2010)
  • unique molecules with presenilin-related expression and functions that may play important role(s) in the maturation and activity of the gamma-secretase complex (Araki 2008)
  • Orm proteins are critical mediators of sphingolipid homeostasis, raising the possibility that sphingolipid misregulation contributes to the development of childhood asthma
  • ORMDL1, ORMDL2, ORMDL3 are the primary regulators of ceramide biosynthesis in mammalian cells, and constitute the major homeostatic regulators of ceramide biosynthesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SPTLC1 activity indirectly regulates ORMDL1, ORMDL2, ORMDL3 expression 2)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • may be a critical mediator of sphingolipid homeostasis and with sphingolipid dysregulation might contribute to the development of childhood asthma (Breslow 2010)
    • Marker
    Therapy target
    ANIMAL & CELL MODELS