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FLASH GENE
Symbol OPRK1 contributors: mct - updated : 27-01-2016
HGNC name opioid receptor, kappa 1
HGNC id 8154
Location 8q11.23      Physical location : 54.138.275 - 54.164.194
Synonym name opiate receptor, kappa-1
Synonym symbol(s) KOR-1, OPRK, KOR, KOPr
DNA
TYPE like-sequence
STRUCTURE 25.98 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
FLJ25471 8q11.22 hypothetical protein FLJ25471 BTF3P1 8q11.22 basic transcription factor 3, pseudogene 1 LOC115294 8q11.22 similar to hypothetical protein FLJ10883 LOC389657 8 LOC389657 ST18 8q11.21 suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein) LOC389658 8 similar to RPLK9433 RB1CC1 8p22-q11.23 RB1-inducible coiled-coil 1 GPR7 10q11.2-q21.1 G protein-coupled receptor 7 LOC392219 8 similar to ring finger protein 2 OPRK1 8q11.2 opioid receptor, kappa 1 LOC392220 8 similar to L21 ribosomal protein MAPK6PS1 8q11.23 similar to L21 ribosomal protein ATP6V1H 8p22-q22.3 ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H RGS20 8q11.22-q11.23 regulator of G-protein signalling 20 TCEA1 3p22-p21.3 transcription elongation factor A (SII), 1 LYPLA1 6pter-p25.1 lysophospholipase I TDGF5 8q11.23 teratocarcinoma-derived growth factor 5, pseudogene MRPL15 8q11.2-q13 mitochondrial ribosomal protein L15 LOC392221 8 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein SOX17 8q11,22 SRY (sex determining region y)-box 17 LOC389659 8 hypothetical gene supported by BC028018 LOC392222 8 similar to RIKEN cDNA 0610038D11 LOC157708 8q11.23 similar to SPC18 protein RP1 8q11.21-q11.23 retinitis pigmentosa 1 (autosomal dominant) LOC392223 8 similar to ribosomal protein L7-like 1 LOC389660 8 similar to polycystin 1-like 3 LOC392224 8 similar to hypothetical protein 4932417K07 KIAA1889 8q11.23 KIAA1889 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 5196 - 291 - 1995 7869844
4 - 4959 - 380 - 1995 7869844
- - 5022 - 409 - 1995 7869844
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousgangliasensory gangliadorsal root  
Reproductivefemale systemplacenta   
 male systemprostate   
Visualeyeanterior segment    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
conjugated GlycoP , LipoP
HOMOLOGY
Homologene
FAMILY G protein coupled receptor superfamily
CATEGORY receptor
SUBCELLULAR LOCALIZATION     plasma membrane
text
  • localized to nonpigmented ciliary epithelia
  • basic FUNCTION
  • opioid receptor kappa, both pre- and post synaptically detected, transported to the axons
  • inhibiting a G protein-modulated K+ channel
  • EGF-stimulated axon extension during development is mediated, at least partially, by specific elevation of OPRK1 production at posttranscriptional level, as well as activation of OPRK1 signaling
  • OPRK1 -mediated reduction in intraocular pression could be caused, in part, by NO production in both the ciliary body and the trabecular meshwork
  • OPRK1 activates MAPK14 through a phosphorylation and arrestin-dependent mechanism
  • likely modulate GABAergic synaptic responses and ethanol effects as one of multiple opioid system-dependent actions of ethanol in the central amygdala (CeA), possibly in a circuit-specific manner
  • during hypoxia, the expression of OPRK1 increased in the pulmonary artery
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • APLN forms a heterodimer with OPRK1 and leads to increased PKC and decreased protein kinase A activity leading to a significant increase in cell proliferation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • stimulation of OPRK1, the endogenous receptor for the dynorphin-like peptides, inhibits dopamine release in the striatum (nucleus accumbens and caudate putamen) and induces a negative mood state
  • addition of OPRK1 agonists to KDR vascular progenitors inhibited endothelial cells differentiation and vascular formation
  • YWHAZ promotes expression of the OPRK1 by inhibiting COPI and RVR motif-mediated endoplasmic reticulum localization machinery
  • interaction between OPRK1 and its native peptide ligand PDYN
  • RGS2 and RGS4 are new interacting partners that play key roles in G protein coupling to negatively regulate OPRK1 signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    OPRK1 promoter hypermethylation might increase the risk of Alzheimer through its regulation on the gene expression of OPRK1
    Susceptibility
  • to opiate addiction
  • to alcohol dependence
  • Variant & Polymorphism SNP , other
  • 36G > T SNP was significantly higher among heroin-dependent individuals compared with control subjects
  • polymorphisms increasing the risk of alcohol dependence
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurosensorialvisualanterior chamber
    agonists reduce intraocular pression by reducing aqueous humor formation and increasing aqueous humor outflow, thereby suggesting their possible usefulness in glaucoma therapy
    ANIMAL & CELL MODELS
  • Oprk1 stimulation inhibits TLR4/NfkB signaling in the rat heart subjected to myocardial ischemia and reperfusion (MI/R)